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Thalassemia
Thalassemia is an inherited blood disorder wherein the body forms abnormal hemoglobin – the protein in the red blood cells carrying oxygen. This disorder leads to excessive destruction of red blood cells, which results in anemia.
107 Questions
How stopped to pass beta thalassemia in your unbirth baby?
To reduce the risk of having a baby with beta thalassemia, prospective parents can undergo genetic counseling and testing to determine if they are carriers of the disease. If both parents are carriers, options such as in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) can be considered to select embryos without the condition. Additionally, prenatal testing during pregnancy can help identify if the fetus has beta thalassemia, allowing for informed decisions.
Can Thalassemia prevent Malaria?
Thalassemia itself does not prevent malaria, but individuals with thalassemia trait or certain forms of thalassemia may have a degree of protection against severe malaria due to the altered shape and function of their red blood cells. This change can make it more difficult for the malaria parasite to survive and reproduce. Consequently, while thalassemia does not prevent malaria infection, it can potentially reduce the severity of the disease in affected individuals.
Is thalassemia a sex linked gene?
No, thalassemia is not a sex-linked genetic disorder; it is an autosomal recessive condition. This means that it is caused by mutations in genes located on non-sex chromosomes, specifically the alpha or beta globin genes. Both males and females can be carriers and affected by thalassemia equally, regardless of their sex.
No. The trait that causes sickle cell anemia is a recessive trait, which means that if both parents have the trait, there is a 1/4 chance their child will have it. The child can be a carrier however and not display symptoms, but there is no way for a child to get sickle cell from parents that don't have the gene.
Is cooley anemia sex-linked trait or autosomal trait?
Cooley's anemia, also known as beta-thalassemia, is an autosomal recessive genetic disorder. This means that both copies of the gene must be mutated in order for the disease to be present. It is not a sex-linked trait.
Does thalassemia related to blood group and Rh factor?
No, thalassemia is a genetic blood disorder that affects the production of hemoglobin in red blood cells. Blood group and Rh factor are determined by different genetic markers and are not directly linked to thalassemia.
Is thalassemia sex-linked trait?
Down syndrome results from a nondisjunction during cell division. That is, homologous chromosomes 21 fail to separate in meiosis I, or sister chromatids 21 during meiosis II or mitosis.
Down syndrome is caused by trisomy of chromosome 21 (an extra chromosome to the usual two), which is an autosomal chromosome. Therefore it is not a sex linked disorder.
What mutations does beta-thalassemia have on DNA?
Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.
What is the major difference between thalassemia and sickle cell anemia?
Thalassemia is a quantitative problem of too few globins synthesized, whereas sickle-cell anemia (a hemoglobinopathy) is a qualitative problem of synthesis of an incorrectly functioning globin. (wikipedia)
Is sickle cell anemia a point mutation?
An example of point-mutation is sickle-cell anemia. Sickle-cell disease is hereditary.
People whose hemoglobin does not produce enough beta protein have beta thalassemia. It is found in people of Mediterranean descent, such as Italians and Greeks, and is also found in the Arabian Peninsula, Iran, Africa, Southeast Asia and southern China.
There are three types of beta thalassemia that also range from mild to severe in their effect on the body.
Thalassemia Minor or Thalassemia Trait. In this condition, the lack of beta protein is not great enough to cause problems in the normal functioning of the hemoglobin. A person with this condition simply carries the genetic trait for thalassemia and will usually experience no health problems other than a possible mild anemia. As in mild alpha thalassemia, physicians often mistake the small red blood cells of the person with beta thalassemia minor as a sign of iron-deficiency anemia and incorrectly prescribe iron supplements.
Thalassemia Intermedia. In this condition the lack of beta protein in the hemoglobin is great enough to cause a moderately severe anemia and significant health problems, including bone deformities and enlargement of the spleen. However, there is a wide range in the clinical severity of this condition, and the borderline between thalassemia intermedia and the most severe form, thalassemia major, can be confusing. The deciding factor seems to be the amount of blood transfusions required by the patient. The more dependent the patient is on blood transfusions, the more likely he or she is to be classified as thalassemia major. Generally speaking, patients with thalassemia intermedia need blood transfusions to improve their quality of life, but not in order to survive.
Thalassemia Major or Cooley's Anemia. This is the most severe form of beta thalassemia in which the complete lack of beta protein in the hemoglobin causes a life-threatening anemia that requires regular blood transfusions and extensive ongoing medical care. These extensive, lifelong blood transfusions lead to iron-overload which must be treated with chelation therapy to prevent early death from organ failure.
From Jagadish
What is the best way to treat iron deficiency anemia?
Treatment for iron-deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery.
Severe iron-deficiency anemia may require a blood transfusion, iron injections, or intravenous (IV) iron therapy. Treatment may need to be done in a hospital.
The goals of treating iron-deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells, hemoglobin, and iron.
What Diseases are caused by lack of sunshine?
The many health benefits of sunlight are discussed, such as relief from depression, improved digestion and an increase in your metabolism.
Also, Vitamin D is the nutrient received from sunlight.
Active vitamin D is a potent immune system modulator. There is plenty of scientific evidence that vitamin D has several different effects on immune system function that may enhance your immunity and inhibit the development of autoimmunity.
It also maintains your calcium balance.
Can abcessed tooth cause other health problems?
Yes. There have been many reported incidences of chronic conditions improving when an abscessed tooth is properly dealt with.
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Abscess is caused by an infection and if not treated bacteria can spread trough the blood stream and damage various organs and lead to life threatening conditions. Here's a short video about abscess causes and treatment -
http://www.checkdent.com/en/videos/tooth-abscess-9.html
What do you mean by clinical manifestations?
Clinical manifestations are the observable symptoms by which a disease may be diagnosed by a physician. It is how a disorder 'manifests' itself to an observer.
How do you treat patients that suffer from anemia be treated?
My brother had iron-deficiency anemia as a kid and he had to take pills to help raise his iron-levels. There are also iron-filled foods that can raise the level naturally, including beans and spinach. (It wasn't Popeye's source of strength for no reason.)
You have tingling down whole of your left side of body from head to toe?
consult a doctor immediately as this could be the early symptoms of a serious problem.
What does the term thalassemia minor refer to?
If untreated, beta thalassemia major can lead to severe lethargy, paleness, and delays in growth and development. The body attempts to compensate by producing more blood, which is made inside the bones in the marrow.
What are the causes of thalassemia?
All types of thalassemias are recessively inherited, meaning that a genetic change must be inherited from both the mother and the father. The severity of the disease is influenced by the exact thalassemia mutations inherited, as well as.
What organs are just below the belly button area?
The stomach and heart/lungs.... This person who previously answered this question with just those 3 things also forgot some major organs... Pancreas, Liver, Upper Intestines, Lower Intestines (the L.I. are right behind the belly button)
How do you prevent and avoid tongue diseases?
1 have o good hygiene
2 when brushing your teeth scrape your tongue gently too
3 eat healthy
4 don't sip too hot soup/liquid
5 don't put sharp objects in your mouth
6 don't lick dirty objects to avoid infection
7 avoid too spicy food
8 always gargle or rinse your mouth after eating
9 don't swallow inedible object esp chemicals
10 avoid tongue piercing as much as possible
What is the treatment for beta thalassemia?
Thalassemias, (alpha, beta, and their subdivisions) are genetic disorders, affecting the number and the oxygen/carbon dioxide carrying ability of the erythrocytes. The later is due to defective heamoglobin structure.
The disease's severity depends on the severity of the defect, and the treatment likewise. For example, defect in Alpha thalassemia silent is very mild, therefore treatment might not even be necessary.
Treatments for the more severe types include blood transfusion, iron chelation, vitamin and folic acid supplementation, surgical removal of the spleen (in Alpha thalassemia major).
Researches into new treatments include donor blood and marrow stem cell transplantation, gene therapy, and activation of fetal haemoglobin.
How can blood transfusion help thalassemia patients?
There are a few reasons why a person should receive a blood transfusion, lets start off with the most common:
- Your hemoglobine(Hb) concentration is very low(around 5,5 mmol/L, differs from hospital), in other words, you have an anemia(You have an anemia when: for women at 7,5 mmol/L, men at 8,0mmol/L).
Receiving a blood transfusion will increase your hemoglobine concentration with approx. 1,5 mmol/L each erythrocyt unit(One bag of concentrated erythrocytes).
There are alot of causes for a low Hb, a few examples are:
iron deficiency, blood lost, auto-immune illness(Your own body is destroying its own erythrocytes) or low production of erythrocytes.
- Thallassemia, This is an disorder of your bone marrow. With this disorder your bone marrow is not able to create hemoglobine the right way. It is able to make erythrocytes, but no good ones. Your liver and milt filters of the blood and will detect these bad erythrocytes and destroy them. People with this disorder have to receive a blood transfusion monthly. The only cure is to receive a bone marrow donation.
- Your coagulation is drastically slow. You will not receive a normal bag of erythrocytes, but a bag of blood plasma. This plasma still contains the coagulation proteins(Factors, example: factor VII etc.). With these you will get your coagulation faster, else risks are you will have a high chance of bleedings.
- Your trombocytes are very low. You will receive a bag of concentrated trombocytes. You will receive these when your trombocytes are below 50 /fL(may varray per hospital).
This is a short answer to your question, other reasons may be added by other people.
Can people with Thalassemia Major reproduce?
As long as their reproductive growth is at the stage of reproduction they can reproduce. Thalassemia Major is a blood disease affecting the red blood cells, which cause mild to severe anemia. It is also hereditary.
