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They are both located on the North Amercian continent.

Both colonies were founded in the 1600s.

They were both havens of religious freedom; Massachusetts primarily had the Puritans, and Pennsylvania primarily had the Quakers.

Both areas were rich in Natural Resources, such as lumber.

While the Massachusetts Bay Colony was at first the most populous as well as the most economically significant with it's sizable merchant fleet, the rapid growth of Philadelphia soon made it America's most important city, opening the first hospital in the British American colonies in 1751.

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