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The Santa Fe Expedition of 1841 was significant for Texas as it aimed to assert Texas's claim over the Santa Fe region and expand its influence into New Mexico. Although the expedition ultimately failed due to logistical challenges and hostile encounters, it highlighted the tensions between Texas and Mexico, and underscored the challenges of frontier expansion. The expedition also galvanized public opinion in Texas regarding its ambitions for territorial growth and contributed to the ongoing narrative of Manifest Destiny in the United States.

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