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It has been theorized that excess stored iron can lead to atherosclerosis and ischemic Heart disease.
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How is excess stored iron in the body treated?
Phlebotomy, or blood removal, has been used with some success. Iron chelation using drugs such as desferrioxamine help patients excrete excess stores of iron.
How is iron stores and transported in the body?
Iron taken in excess is stored in two forms ferritin and hemosiderin. Iron that is not used for erythropoiesis is stored in the mononuclear phagocytic system (MPS) or the reticloendothelial (RE) cells of the bone marrow, liver, and spleen. The body transports iron in hemoglobin which is the substance in the red blood cells which binds to oxygen to transport to the whole body.
Where does the iron on the body go?
In the human body iron is stored in the red blood vessels.
How horrible is it to be low on iron in your body?
An iron deficiency results in anemia. An excess of iron causes hemochromatosis.
Is hemochromatosis known as iron overload disease?
yes it is. it is a condition where excess amounts of elemental iron is stored to other organs in the body. iron is essential for one purpose only, hemoglobin synthesis. excess amounts is excreted in the feces. the body gets overwhelmed when excess amounts gets into the circulation, eg. repeated blood transfusions. deposition to targets organs causes damage and disease... you can check my site for articles in internal medicine lowellmd202.blogspot.com
Where is excess iron stored in the body?
Iron overload can be caused by multiple blood transfusions. Please don't stop there ! Excess iron can easily occur due to taking dietary supplements such as the ones some women take for certain medical problems . An excess of iron (about two times the "daily requirement" will lead to iron poisoning and quite possibly death . Please consult with a real doctor when you start playing around with your health . Far too many simple things that we have access to in our homes can kill you if used incorrectly . If you don't have a doctor, talk to a pharmacist, they can help put you on a safe track.
What does desferoxamine do?
It helps the body to eliminate excess iron through the urine
What are iron tests?
a group of blood tests that are done to evaluate the iron level in blood serum, the body's capacity to absorb iron, and the amount of iron actually stored in the body.
Where ferritin is produced in body?
Ferritin is produced in nearly every cell in the body. Ferritin is a large protein that stores up to 4,500 iron atoms in its core. Iron has to be stored because we only absorb 10% of iron from our food meaning it is difficult to obtain and iron tends to participate in harmful free radical forming chemical reactions. Iron also cannot exist in the body by itself. Each atom has to be attached to a protein or small molecule (chelator) at all times or it will precipitate out of solution and will form rust in the body somewhat similar to the form it exists when it is stored in ferritin. Thus the need for ferritin to be produced by nearly all cells in the body, so there can be a reserve of iron in the body to supply the much needed iron and remove excess iron that could be harmful.
Why has too much blood can harm us?
Too much blood in the body is known as Hemochromatosis; an excess of iron. This can harm us because it can cause liver and heart problems, cancer, diabetes and thyroid deficiency.
Which is major storage form of iron in the body?
Ferritin is a protein that stores iron and releases it in a controlled fashion. Hence, the body has a "buffer" against iron deficiency (if the blood has too little iron, ferritin can release more) and, to a lesser extent, iron overload (if the blood and tissues of the body have too much iron, ferritin can help to store the excess iron).
What substances are stored in the liver?
There are many substances stored in the liver that are important for the body. Among these are glucose, vitamins A, D, K, and B12, along with iron and copper.
