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Yes, you can get an allergic reaction to Gypsum. It is possible to have a contact reaction that can produce severe itchy skin, reddening and can also create a feeling that the skin is "on fire". This is rare and occurs mostly with people that are highly allergic to sulfates or sulfur. Gypsum is a very soft mineral composed of calcium sulfate dihydrate (CaSO4-2H2O) [chacha.com]

Gypsum is used most commonly in drywall, fertilizers and tofu. It is the most common form of sulfur.

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Q: Can you get an allergic reaction to gypsum plaster - such as severe itchy skin?
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