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How is sickle cell trait different from sickle cell disease and what are the key distinctions between the two conditions?
Sickle cell trait and sickle cell disease are both genetic conditions caused by a mutation in the hemoglobin gene. Sickle cell trait means a person carries one copy of the mutated gene, while sickle cell disease means a person has two copies. The key distinction is that individuals with sickle cell trait usually do not experience symptoms, while those with sickle cell disease can have severe health issues such as pain crises, anemia, and organ damage.
Is Sickle cell anemia inherited?
This is inherited on the X chromoseome and is recessive. This means a female (who has XX chromosome pair) can only express the disease if she carries the trait on both chromosomes. This is because of the recessive nature of the gene. A male can only inherit the disease from his mother. This is he must have obtained his Y chromosome from his father so he obtains the X chromosome from his mother. A male cannot carry the gene without expressing it as he doesnt have another X chromosome to supress the recessive gene. ^ This answer is biologically incorrect because Sickle cell Anemia is actually autosomal recessive, not sex-linked recessive; this means that males and females are affected equally and it is NOT carried on the X chromosome. In order for the trait to show up in an individual, BOTH parents must be carriers of the disease (at least 1 sickle cell gene must be present).
What does AS and SS under blood group mean?
Under blood group, the letters AS and SS are used in reference to sickle cell disease. AC means that one is carrying the sickle cell disease gene while SS means that one has sickle cell disease.
What are the different types of sickle cell disease and how do they differ from each other?
There are several types of sickle cell disease, including sickle cell anemia, sickle beta thalassemia, and sickle cell-hemoglobin C disease. These types differ based on the specific genetic mutations that affect the hemoglobin protein in red blood cells. Sickle cell anemia is the most common and severe form, where individuals have two copies of the sickle cell gene. Sickle beta thalassemia and sickle cell-hemoglobin C disease are milder forms that result from different combinations of genetic mutations. Symptoms and complications can vary among the different types of sickle cell disease.
Is sickle cell anemia inherited as a dominant or recessive trait, and how does this inheritance pattern impact the likelihood of developing the condition?
Sickle cell anemia is inherited as a recessive trait. This means that a person needs to inherit two copies of the sickle cell gene (one from each parent) to develop the condition. If only one copy of the gene is inherited, the person is a carrier but does not have the disease. This inheritance pattern impacts the likelihood of developing the condition because both parents must be carriers for there to be a chance of their child having sickle cell anemia.
Is sickle cell anemia a single gene defect or multiple gene?
Sickle Cell Anaemia is a single gene defect (Hb gene).
What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?
The condition is called sickle cell trait. This occurs when an individual inherits one sickle cell gene and one normal hemoglobin gene, resulting in milder symptoms compared to sickle cell disease.
Can child be born with sickle cell if one parent is sickle cell carrier and another is normal?
A child has to receive the gene from both parents to heve sickle cell anemia. if only one parent passes on the gene, then the child will have sickle cell trait, but no symptoms of sickle cell anemia.
Who has a sickle cell trait?
People who inherit one sickle cell gene are said to have sickle cell trait. This means they carry the gene but do not typically have symptoms of sickle cell disease. It is important for individuals with sickle cell trait to be aware of their status for proper medical management and genetic counseling.
What does it mean when someone carries the sickle cell gene but does not have the disease?
If you carry the sickle cell gene, it doesn't really mean much as far as your own personal health goes. Except that you are less likely to get malaria. However, if you decide to have kids, and whoever you mate with also carries the sickle cell gene (not the full blown disease/gene) , your child has a chance of having sickle cell disease (full blown).
What are the chances of a person having a sickle cell disease passing the disease to their offspring?
If one represents a sickle cell gene thus "C" and a normal gene thus "O" then both parents are: Mum CO Dad CO The possibilities for their children are therefore CC OO CO CO in those proportion so 1in 4 will have sickle cell anaemia, 2 in 4 will be carriers (like their parents) and 1/4 will be normal.
Is sickle cell a one gene disorder?
No, it's not a one gene disorder
Are sickle cell anemia and sickle cell trait the same?
No, sickle cell anemia and sickle cell trait are not the same. Sickle cell anemia is a severe form of the disease caused by inheriting two sickle cell genes (one from each parent), leading to significant health complications. In contrast, sickle cell trait occurs when an individual inherits only one sickle cell gene and one normal gene, typically resulting in no symptoms but allowing the person to pass the trait to their offspring.
What is requires for a person to have sickle cell disease?
The person is homozygous for the trait
What part of the gene carries the information for sickle cell anemia?
you dont have to worry about getting sickle cell if your not african american
What is the genotype of a man who has sickle cell trait?
rr since sickle cell is a recessive trait.
What condition is a person with only ONE sickle cell gene and one normal hemoglobin gene more capable of surviving than someone who has no sickle cell genes?
A person with one sickle cell gene and one normal hemoglobin gene has sickle cell trait, which can provide some protection against malaria. This advantage makes them more capable of surviving in regions where malaria is prevalent compared to someone with no sickle cell genes, who would be more susceptible to severe malaria infection.
