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not really, but they do tell you not to mix suboxone with downers because it lowers your blood pressure but i've done it a million times and been fine. but for some people, suboxone makes it really hard for them to sleep, so it might interact that way, maybe making it harder to sleep. but then again the lunesta could get rid of the insomnia from suboxone. basically, its not one of those deadly drug combinations. so while it may effect you different than someone else, its not life-threatening to take together.

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12y ago
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Q: Does suboxone interact with lunesta
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