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The best way would be to take it to an expert, in this case a dry cleaner. If you don't want to do that, you could tryusing fingernail polish remover, but you should try it in a tiny, inconspicuous area first to see if it has any adverse effect on either the material or dye used in the comforter (if it's made of synthetics, there's at least a reasonable chance fingernail polish remover will dissolve the fabric).

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Q: How do you remove fingernail polish from a comforter?
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