The new (05-07) superduties are a bit different then the old ones and will require the whole dash to be removed. It ain't pretty, and it can be difficult if you don't know what you are doing. However, I found a nice guide that will help. Check this link and good luck. http://docs.Google.com/viewer?a=v&q=cache:mgB3IovjbPQJ:www.richgann.com/radioremoval.pdf+Ford+f350+remove+radio&hl=en&gl=ca&pid=bl&srcid=ADGEEShXGBxaWfpMf0KbmF4etF7ajMop_YkOof5FUBTL6hGGehIODbCg5Jq910gHSvRFZ6-AVy0kVOjg24gLbd7Ffr-paai1ZPvKSbCLeQXUDqWvko26El1W_CSSvVxwHL8yC2URkIFi&sig=AHIEtbSESNskEIYkRAoF23K-gwLvMT2xIQ
You must buy a Ford Factory Stereo Removal Tool. then pull the radio forward and unplug the wiring in the back.
See http://wiki.answers.com/Q/How_do_you_remove_the_radio_from_a_2006_Ford_F350
it is under the dash, nearly uner the radio in a black box
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there is a tool that u need u can get at wal-mart looks like a u the size off metal coat hinger
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6 1/2