How is gastric acid produced?

Answer 1

Gastrin is a hormone released by "g" cells in the stomach. This hormone stimulates gastric secretions, including hydrochloric acid (HCL). The release of gastrin is initiated by:

distention of the stomach

impulses from the vagus nerve as from sight or smell of food

presence of liquids or partially digested proteins in the stomach

I hope this answers the question!

Answer 2

· Regulation of Gastric Secretion: Parasympathetic innervations via the vagus nerve is the strongest stimulant of gastric H+ secretion. Vagal efferent activity activates parietal cells to secrete H+. Parasympathetic activation also releases gastrin from G cells. Gastrin enters the bloodstream and, via an endocrine mechanism, further stimulates the parietal cell to secrete H+. Control of the H+ Pump: Binding of histamine to receptors on parietal cells activates adenylyl cyclase and elevates cytosolic concentration of cAMP. This stimulates H+ secretion by activating basolateral K+ channels (K+ out) and apical Cl- channels (Cl- into lumen) and by causing more H+,K+-ATPase molecules and Cl- channels to be inserted into the apical membrane. Ach promotes the release of Ca++ from intracellular stores, which enhances H+ secretion by doing the same thing cAMP does. Gastrin enhances acid secretion by binding CCK receptors and releasing Ca++ from intracellular stores like Ach.