It depends on where you are going in Louisville. From Frankfort to the east side of Louisville the drive is 35-40 minutes.
4 hours
According to MapQuest and depending on where you start out in Louisville and go to in Birmingham, it will take at least 5 hours and 35 minutes to drive.
Almost 14 hours.
5 hours
According to mapquest.com, it will take approx. 16 1/2 hours to drive the 1083.76 miles from Miami Florida to Louisville Kentucky.
It will take an estimated 5 hours and 55 minutes to drive from Albany, NY to Erie, PA. There are 377 miles between the two cities.
34 hours
Chigago IL to Louisville, KY, USA 297 mi - about 4 hours 47 mins
The shortest time is 5 hours and 25 minutes.
It takes about 9-12 hours.
It is 106.67 miles according to MapQuest.