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Well, a cylinder is a hole, so you can't replace it... but there could be a few reasons why you have a mis-fire: Damaged spark plug wire

Fouled / damaged spark plug

Head gasket leak (unlikely)

Bad / burnt valves

Hole in a piston

Bad piston rings

Other things depending on the year and manufacturer of the engine... There are a bunch of tests you can run to determine what the problem maybe if you have the tools. You might try looking into an automotive forum for you make and model... chances are they've already got pretty lengthy discussion on it.

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Q: If you have a V8 and the number 2 cylinder is mis-firing do you need to replace all cylinders?
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