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Misfire can be caused by any condition that doesn't allow for full combustion in an engine. You don't specify what engine you have in your Ranger, but look for things common to both cylinders. Are they on the same ignition coil? Are they next to each other on the engine? Causes can be almost anything, from a bad spark plug to a mechanical fault in the engine itself. I cover this information in my upcoming book Automotive Driveablity: A Guide to Engine Performance Diagnosis. Feel free to visit me at www.autoservicetech.com. I also recently wrote an article on misfire diagnosis for MotorAge magazine that will be listed on my home site soon.

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Q: What can cause cylinders 2 and 4 to misfire on a 2001 ranger?
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