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Chromosome 11

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15y ago

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Where is the beta globin gene?

The beta globin gene is located on chromosome 11 in humans. It codes for the beta globin protein, which is a subunit of hemoglobin found in red blood cells. Mutations in this gene can lead to conditions such as sickle cell anemia and beta thalassemia.


What chromosome is the HBB gene on?

The HBB gene, which codes for the beta globin protein, is located on chromosome 11.


Why is a specific region of chromosome 11 referred to as the globin gene cluster?

Due to its relation with formation of globin.


How many copies of the beta globin gene do people have?

Most individuals have two normal copies of the beta globin gene


What chromosome number is affected in sickle cell disease?

Sickle cell disease is caused by a mutation on chromosome 11, specifically in the HBB gene that codes for the beta-globin protein. This mutation leads to the production of abnormal hemoglobin, resulting in the characteristic sickle-shaped red blood cells.


Is sickle cell anemia an autoimmune disease?

Sickle Cell Anemia is Autosomal Recessive. It arises from a mutation on the beta-globin gene of chromosome 11. Because Sickle Cell Anemia is an example of incomplete dominance, a person has the disease if they have two mutated beta-globin genes but only has the trait (is a carrier) if they have only one mutated beta-globin gene.


What is the DNA code for normal hemoglobin?

The DNA code for normal hemoglobin is the gene that encodes for the production of the protein hemoglobin. The sequence of this gene includes instructions for building the alpha and beta globin chains that make up the hemoglobin protein. This gene is located on chromosome 11 in humans.


What mutations does beta-thalassemia have on DNA?

Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.


What is the mRNA sequence for a person with sickle cell anemia?

For sickle cell anemia, there is a single-point mutation in the beta-globin gene. The mutation causes a change in the mRNA sequence from GAG to GTG, resulting in the substitution of glutamic acid with valine at the 6th position of the beta-globin protein.


Adenine and thymine mutation in sickle cell?

yes. thymine replaces adenine in the dna that codes for the amino acid on the 6th position of the beta globin chain resulting in an amino acid change of glutamic acid to valine. shari (med student - jamaica)


What various types of genetic material in order from simplest to most complex?

nucleus → chromosome → gene


List these in order from smallest to largest chromosome gene cell?

Smallest to largest: Gene (a place on a chromosome); chromosome (there are 46 in human cells); and DNA (because it accounts for all the genetic material in a cell).