When the Ach binds to receptor sites on the muscle cell membrane it causes channels to open and allows Na+ to move into the cell which then causes an action potential.
Motor end plate
junctional folds?
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
it is an alpha-toxin that binds to acetylcholine binding sites on the postsynaptic cell membrane, which prevents the acetylcholine from acting. Curare blocks synaptic transmission by preventing neural impulses to flow from neuron to neuron. It does allow the action potential to travel in the axon, it just doesn't pass it on to the dendrite.
Depolarization
The receptors for ACh are non selective ligand-gated channels that once are bound by ACh allow Na and K to flow through...this depolarizes the membrane and cause VOLTAGE gated sodium channels to open and cause an action potential
Acetylcholine receptors at neuromuscular junctions are affected in MG. MG is an autoimmune disorder in which the body produces antibodies against its own protein, the acetylcholine receptor. These antibodies block the receptor, preventing the binding of acetylcholine and inhibiting the function of the receptor, which is to initiate a depolarization in muscle cells that will lead to contraction. Fewer available acetylcholine receptors means greater stimuli, i.e. more acetylcholine has to be released to cause a contraction. This manifests physically as serious weakness resulting from inability to move muscles at will. The name of the disease describes the symptoms quite well (my-, muscle; -a-, without; -sthenia, strength; gravis, heavy, serious).
Β binding of acetylcholine to membrane receptors on the sarcolemma
Acetylcholine
Sarcolema receptors
Curare is a competitive inhibitor of acetylcholine. It fights with acetycholine for postsynaptic receptors.
from answers.com When a nerve impulse reaches an axon ending, voltage-gated calcium channels in the axonal membrane open and calcium, which is extremely low inside the cell, enters the nerve ending. The increase in calcium-ion concentration causes hundreds of synaptic vesicles to fuse with the cell membrane and expel acetylcholine into the synaptic cleft (exocytosis). The acetylcholine released at a neuromuscular junction binds reversibly to acetylcholine receptors in the muscle end-plate membrane, a postsynaptic membrane that is separated from the nerve ending by a very short distance. The receptor is a cation channel which opens when two acetylcholine molecules are bound, allowing a sodium current to enter the muscle cell and depolarize the membrane. The resulting impulse indirectly causes the muscle to contract.
If the acetylcholine receptor was destroyed that the effector cells cannot respond or detect the neurotransmitter, resulting in muscle paralysis.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
The neurotransmitter acetylcholine is released into the synaptic cleft to bind with receptors on muscle cells. Upon binding, the muscle cells contract.
Acetylcholine (ACh) is the only neurotransmitter used in the motor division of the somatic nervous system. It works by binding to acetylcholine receptors on skeletal muscle fibers and opening ligand-gated sodium channels in the cell membrane.
Acetylcholine (ACh) is the only neurotransmitter used in the motor division of the somatic nervous system. It works by binding to acetylcholine receptors on skeletal muscle fibers and opening ligand-gated sodium channels in the cell membrane.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
Acetylcholine (ACh)