pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK)
The inhibitory effect of glucose on phosphoenolpyruvate carboxykinase gene expression in cultured hepatocytes is transcriptional. It requires glucose metabolism.
pyruvate
During gluconeogenesis, acetyl CoA is converted into glucose through a series of enzymatic reactions in the liver and kidneys. Acetyl CoA is first converted into oxaloacetate, which is then converted into phosphoenolpyruvate. Finally, phosphoenolpyruvate is converted into glucose. This process requires energy in the form of ATP and involves several key enzymes such as pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and fructose-1,6-bisphosphatase.
Phosphoenolpyruvate (PEP)
Enzymes involved in the formation of glucose include glucose-6-phosphatase, which converts glucose-6-phosphate to glucose, and phosphoenolpyruvate carboxykinase, which catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the gluconeogenesis pathway. These enzymes play a crucial role in maintaining blood glucose levels during fasting or starvation.
Some substitutes for rubisco include enolase, PEP carboxylase, and phosphoenolpyruvate (PEP) carboxykinase. These enzymes can have higher affinities for carbon dioxide, reducing the rate of photorespiration in plants.
This reaction is a phosphorylation reaction where phosphoenolpyruvate transfers a phosphate group to ADP to form pyruvate and ATP. It is catalyzed by the enzyme pyruvate kinase, an important step in glycolysis for ATP production.
In the anabolism of glucose, pyruvate is initially converted into phosphoenolpyruvate (PEP) through the enzyme pyruvate carboxylase. PEP is an important intermediate in the gluconeogenesis pathway, which synthesizes glucose from non-carbohydrate precursors.
Gluconeogenesis is a metabolic pathway that converts non-carbohydrate sources like amino acids and glycerol into glucose. It occurs mainly in the liver and kidneys to maintain blood glucose levels during fasting or low carbohydrate intake. Key enzymes involved in this pathway include pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and fructose-1,6-bisphosphatase.
No, it is not true. PEP, or phosphoenolpyruvate, is actually a substrate for phosphofructokinase (PFK), a key enzyme in glycolysis. PEP is converted to fructose-1,6-bisphosphate by PFK, which is an important step in the glycolytic pathway.
I and II