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What is the best route for synthesis of pyridine-4-acetaldehyde?
yes
The surgical procedure to create an alternate route is called a bypass.
Acetanilide
The amide group on acetanilide is an ortho/para director, so a simple nitration should work: a mixture of sulfiric acid and nitric acid should be sufficient. Afterward, separation of the ortho and para compounds (by column chromatography, probably) would be necessary.
Acetic anhydride and aniline are the reactants for the preparation of acetaanilide.
The chemical reaction is:C6H5NH2 + (CH3CO)2O → C6H5NHCOCH3 + CH3COOH
An acetanilide is an amide derived from acetic acid and aniline, once used as an analgesic and antipyretic.
What is the best route for synthesis of pyridine-4-acetaldehyde?
because if the temperature rises it will give o-nitroacetanilide too.
Why is not acetanilide soluble in HCL?
the most suitable for recrystrallizing acetanilide is water..
Yes. Heptane is an ideal recrystallization solvent for acetanilide.
used of para nitro acet anilide
yes
In the synthesis of acetanilide the hydrochloride salt of aniline is used in order to increase the solubility in water. The sodium acetate acts as a base and reacts with the HCl to produce acetic acid. Once the acetanilide product is no longer a hydrochloride salt, its solubility in water is decreased and it crystalises out. The main byproducts are sodium chloride and acetic acid which remain soluble in the water and are removed when the crude product is filtered off.
Acetanilide is a substituted aromatic amide insoluble in water and is almost neutral so does not react with litmus.