route 66
Take I-90 EAST to Boston
Fly
E842 is the best route across. SS16 to A14 connects to that.
Personally I'd probably use the I-80 route.
a popular cattle drive route in the years after the Civil War
The quickest and shortest route is I-5 North.
I-71 South to Columbus, then I-70 West through Indianapolis and on to St. Louis.
Take HIGHWAY 102 NORTH to (TRANS-CANADA) HIGHWAY 104 WEST to AMHERST and NEW BRUNSWICK at EXIT 15W.Take the TRANS-CANADA HIGHWAY on HIGHWAY 104 in Nova Scotia and on ROUTE 2 in New Brunswick to ROUTE 95 TO I-95 to WOODSTOCK and HOULTON, ME at EXIT 188.Take ROUTE 95 to I-95 SOUTH in Houlton, Maine, U.S.A. Continue straight on I-95 SOUTH to Boston.
It is approximately 90 miles if you take the Massachusetts Turnpike, which is by far the best route.
Travel via Indianapolis, Champaign, Bloomington, Peoria and Galesburg for the fastest route at an estimated 8 hours and 5 minutes according to Google Maps.
The best driving route from Calais to the Czech Republic is one that avoids going through Brussels. It takes about 11 hours to drive the distance.