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Amprolium is not an organism, so is not an antibiotic in the sense I think you mean. It is an analog of Vitamin B1, and works by preventing the uptake of thiamine (B1) by the organism which causes coccidiosis. Amprolium makes the creature's body an environment hostile to the development of coccidiosis, without actually attacking the coccidiosis organism. It's like a placebo food for the coccidiosis microbe, which gets no nourishment from it. To some degree amprolium also reduces the uptake of thiamine in the creature who is eating amprolium in its feed, so it is only administered until the young chickens are old enough to have built up an immunity to coccidiosis, from low-level environmental exposure to it. Then they are switched to unmedicated feed. (This is fairly common for management of small poultry flocks; I can't speak about the management of large-scale operations.) Using amprolium does not contribute to drug-resistant microbes.

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Q: What is the drug resistance of amprolium?
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Is it safe to eat the eggs of a hen who eats Amprolium?

Speaking for common small-flock management...not sure what the large-scale operation practice is. Layer chicks are often raised on medicated chick starter, the relevant ingredient of which is amprolium, which is to prevent coccidiosis. (Amprolium is an analog for Vitamin B1 and is not an organism, itself.) The amprolium keeps the coccidiosis microbe at bay in the chicks' bodies until, at eight or nine weeks, the chicks have developed a resistance to coccidiosis from low-level environmental exposure to it, and do not need the amprolium any more, so are switched to unmedicated feed. Hens typically don't start laying until twenty weeks of age, so there is no reason why a laying hen would be eating amprolium-medicated feed any more, anyhow.


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