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You can take Highway 99 out of Vancouver to US I-5. Near Seattle, Washington you will transfer to US I-90 until Sioux Falls, South Dakota. From here you will take US I-29 and continue on US I-435, then merge onto US I-70 in Kansas City, Missouri. In St. Louis, Missouri you will transfer to US I-57, then to US I-24. Taking US I-75 in Chattanooga, Tennessee will navigate you directly to Orlando, Florida.

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Q: What is the most direct land route from Vancouver to Orlando FL if driving?
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