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The relation between Diabetes and melitus is one of Ion balance and solute diuresis. In diabetes melitus there is an increased amount of both Glucose in urine do to low insulin production/none or Insulin resistance. In addition, there is the production of ketoacids from the switch of carbohydrate metabolism to fat metabolism. Both of these act to retain water in the lumen of the kidney and solutes leading to increased loss of solutes due to increased flow rates.

-In the case of K+ the lumen of the kidney is negative due to all the ketoacids present and thus the K+ is attracted stronger to stay in the urine. In addition, the body is trying to maintain the Extracellular fluid balance by reabsorbing Na+ and thus K+ has to act as a counter ion to maintain the electronutrallity of the lumen. Thus producing a double whammy for K+ loss

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Q: What is the relation of hypokalemia to diabetes melitus?
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