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What makes coagulase important for a pathogen?

Updated: 8/11/2023
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Daniellechurch

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13y ago

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There is some controversy about whether coagulase is a virulence factor, but one way coagulase contributes to pathogenicity is that it binds prothrombin to form staphylothrombin, which then cleaves fibrinogen to form fibrin clots in which the bacteria can live and avoid phagocytosis by neutrophils.

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Q: What makes coagulase important for a pathogen?
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What is a free coagulase and its significance?

Free coagulase is an extracellular toxin that reacts with a thrombin-like, thermostable substance known as coagulase-reacting factor (CRF) or serum factor. The reaction of coagulase and CRF will lead to the formation of coagulase-CRF complex where this complex indirectly changes frbrinogen to fibrin (clotting factor) and hence will form a fibrin clot. Furthermore, it is also use as the primary indicator of virulence among staphylococci. Its clinical significance is that when doing the coagulase tube test, the free coagulase will react with the plasma in the tube and hence convert the fribrinogen into fibrin which lead to fibrin clot formation in the tube. This is shown after one day of incubation of the tube, when the tube being invert, the plasma will not go down showing that it is clotted.


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Why is it important asepsis?

Reduces the risk of infection for the patient.


What makes every pathogen unique?

every pathogen is different, the main and only difference is the antigen which live upon it and often release toxins which can also harm the body as well as the actual infection it is carrying. What makes them different are it's Antigens.:)