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The difference is the 750 has larger venturis & throttle plates and flows 150 more CFM at wide open throttle than a 600.

Depending on what models of Holley's you are comparing there could be other differences as well (float bowls, linkage, vacuum secondary vs double pumper, STD flange vs spread bore, etc.).

Your question is very generic so it's hard to give an exact answer aside from the obvious size differences. If you had given the list numbers from both carburetors (located on the choke horn) I/We could give a more detailed answer of the specific differences between the two.

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Q: What the difference with a 750 four barrel holley carb to a 600 holley carb?
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