all parasympathetic target organs
all parasympathetic target organs
Nicotinic receptors are closed until ACh molecules bind to the receptor proteins.
1) nicotinic acetyle choline receptors are ligand gated ion channels, where as mucarinic Ach receptors are G-proteins coupled receptors system. 2) nicotine is a agonist/ muscarine( a toxin produced by certain mushrooms) is a agonist. 3) action of nicotine is fast(1-2msec)/action of muscarinic is slow (100-250msec). 4) in case of nicotinic ach receptor, subtypes based on different subunit composition.muscle and neuronal classification/in case of muscarinic receptor at least 5 receptors subtype have been described by molecular cloning. 5) in case of nicotinic receptor agonist effects blocked by tubocuranine/in case of muscarinic receptor agonist effects blocked by atropine. 6) nicotinic receptor found at neuro muscular junction of skeletal muscle, on the post ganglion neurons of the parasympathetic nervous system and on many neurons on the brain(hypothalamus)/muscarinc receptor found at neuromuscular junction of cardiac and smooth muscle as well as on glands and on the post ganglionic neurons of the sympathetic nervous system.
The acetylcholine diffuses across the synapse and binds to and activates nicotinic acetylcholine receptors on the motor end plate of the muscle cell. Activation of the nicotinic receptor opens its intrinsic sodium/potassium channel, causing sodium to rush in and potassium to trickle out.
Curare is a competitive inhibitor of acetylcholine. It fights with acetycholine for postsynaptic receptors.
Nicotinic; muscarinic
Niacinamide is also known as niacinamide and nicotinic amide. It is the amide of nicotinic acid. Its formula is C6H6N2O.
ACH receptors can be defined as an integral membrane protein that responds to the binding of acetylcholine, a neuoyansmitter. Two example are nicotinic acetyl line receptors and muscarinic acetylcholine receptors. .
The answer is "Niacin"
Nicotinic Aacid
60 mgs will kill you