DNA Polymerase
DNA Polymerase
It's the DNA polymerase that catalyzes the formation of phosphodiester bonds between the nucleotides during replication.
THat would be the enzyme DNA Polymerase III which attaches free floating nucleotides to the parent strand. But remember, they can only be attached to a free 3' position!
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The specific type of mutation resulting from a mistake during DNA replication will depend on the nature of the mistake and the type of nucleotide substitution that occurred. Some possible types of mutations include point mutations (such as a substitution, insertion, or deletion of a single nucleotide), frameshift mutations, or silent mutations.
DNA Polymerase
It's the DNA polymerase that catalyzes the formation of phosphodiester bonds between the nucleotides during replication.
Some mutations are due to errors in DNA replication. During the replication process, DNA polymerase chooses complementary nucleotide triphosphates from the cellular pool. Then the nucleotide triphosphate is converted to a nucleotide monophosphate and aligned with the template nucleotide. A mismatched nucleotide slips through this selection process only onece per 100,000 base pairs at most. The mismatched nucleotide causes a pause in replication, during which it is excised from the daughter strand and replaced with the correct nucleotide. After this so-called proofreading has occurred, the error rate is only one per 1 billion base pairs.
THat would be the enzyme DNA Polymerase III which attaches free floating nucleotides to the parent strand. But remember, they can only be attached to a free 3' position!
a nonsense mutation
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Transcription.
The specific type of mutation resulting from a mistake during DNA replication will depend on the nature of the mistake and the type of nucleotide substitution that occurred. Some possible types of mutations include point mutations (such as a substitution, insertion, or deletion of a single nucleotide), frameshift mutations, or silent mutations.
Mismatch repair ... nucleotide excision repair
Complementary base pairing
Nucleoside and nucleotide analogs inhibit viral replication by incorporating into the viral genome during replication. These analogs lack the necessary functional groups for further elongation of the viral genome, leading to termination of viral replication and inhibition of viral protein synthesis. This disruption ultimately stops the virus from spreading and replicating.
mutation