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Why is leukocyte alkaline phosphatase low in chronic myeloid leukemia?
Wiki User
∙ 11y ago
Hi,
Normal neutrophils have normal amount of LAP while malignant immature neutrophils in CML are deficient in the enzyme. So the leukocytosis seen in a leukemoid reaction ir infection will present with normal or elevated LAP, because the neutrophils are normal, while in CML, the leukocytosis is full of immature neutrophils.
Hope this helps.
Wiki User
∙ 11y ago
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Difference between leukemia and leukemoid reaction?
leukemoid reaction is exaggerated response to infection. leukemoid reaction is benign but its close resemblance to leukemia made it queit worrisome to doctors and needs to be investigated properly. Although qualified hematologist or oncologist usually consulted but generally in leukemoid reaction leukocyte alkaline phosphatase is elevated while its depressed in leukemia, peripheral blood smears show immature forms in leukemia not particularly in leukemoid reaction . By cytogenetics presence of philadelphia chromosome in chronic myelogenous leukemia differentiate it from leukemoid reaction in adults.
What is the definition of chronic myelogenuos leukemia and the definition of chronic lymphocytic leukemia?
What is the definition of chronic bronchitis?
What is the Medical term meaning leukemia?
Leukemia is a medical term, and is group of cancers of of the blood or bone marrow that results in a high leukocyte count (white blood cell count). There are several different types of leukemia including Acute lymphoblastic (ALL), Acute myelogenous (AML), Chronic lymphoblastic (CLL), Chronic mylogenous (CML), Hairy Cell, T-cell, and juvenile. Not all leukemia result in High Leukocyte counts. More often, they result in over all low blood counts.
What does alkaline phosphatas mean?
Alkaline phosphatase removes 5' phosphate groups from DNA and RNA. It will also remove phosphates from nucleotides and proteins. These enzymes are most active at alkaline pH of around 10.5- hence the name.
Is acute leukemia more painful than chronic leukemia?
yes
What is CMMoL?
Chronic myelomonocytic leukemia
Is there a type of leukemia that starts with the letters CM?
CML: Chronic Myeloid Leukemia
Which leukemia is considered more a disease of later life?
Chronic lymphatic leukemia
Is chronic myelomonocytic leukemia cure able?
Yes, there is a red wood which can cure chronic leukemia in just three days, there after no drug is needed. This herb has been tested on manly leukemia patient.
What type of leukemia affects the bone marrow and develops gradually?
Chronic myelocytic leukemia
What type of leukemia that begins slowly and may remain undetected for months or years?
chronic leukemia
What does chronic myeloid leukemia affect?
Chronic Myeloid Leukemia affects genes in the blood cells. Abnormal chromosomes develop and create new genes, these genes allow diseased blood cells to survive. You can learn more about Chronic Myeloid Leukemia at the Mayo Clinic website.
