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Q: Why plasma lactate level increase after prolonged and severe muscular exercise?
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What does lactate cause?

Lactate threshold is caused when lactate production exceeds lactate clearance during exercise or increasing intensity.


What substances increases in muscles during intense exercise?

lactate


What causes a painfulburning sensation in muscles after vigorous exercise?

lactate


A tissue deprived of an oxygen supply during exercise would develop an accumulation of?

lactate


What is the relation between lactate threshold and ventilatory threshold?

They both are reached are approx the same time, it is thought to be that the large change (drop) in blood pH when the lactate threshold is reached is causes ventilation to increase rapidly to try and counteract this blood pH change. The lactate threshold itself is just the point at which lactate removal can no longer keep up with lactate production.


What does the term anaerobic threshold refer to?

it is to describe the phenomenon that takes place in all athletes- namely the maximal speed or effort that an athlete can maintain and still have no increase in lactate. At this speed or effort, lactate levels in the blood remain constant. it is to describe the phenomenon that takes place in all athletes- namely the maximal speed or effort that an athlete can maintain and still have no increase in lactate. At this speed or effort, lactate levels in the blood remain constant.


What is the name of the biochemical pathway describing the conversion of lactate to glucose?

gluconeogenesis or glyconeogenesis. It happens in the cori cicle, for instance - during exercise the muscles use the accumulated glucose to produce energy, producing lactate. Then the lactate goes in the blood stream and is used (mainly) in the liver to produce glucose again


Why does lactate accumulate in the blood during bursts of very vigorous exercise?

Lactate accumulates because of the lack of available oxygen in the muscles. In anaerobic conditions, the pyruvate produced by glycolysis is reduced to lactate via lactate dehydrogenase (while also oxidizing a single molecule of NADH to regenerate NAD+). NAD+ is a very important molecule and must readily be available in the cytoplasm in order for glycolysis to proceed.


What coincides with - but does not necessarily cause- the muscle fatigue and burning pain in the muscles that accompanies intense physical exercise?

build up of lactate


How do you get a cramp?

Muscular cramp occurs when the oxygen demand by muscles is greater than what the body can provide. When the supply is less than the demand, the muscles start to undergo anaerobic respiration - this results in a build-up of lactate in the muscles. When the levels of lactate become too high, the muscles cramp.


Is it possible for a man to lactate?

Yes, a man can lactate for many different reasons. There are tumours that can form on the pituitary gland which increase secretion of the hormone that induces lactation. There is even simple nipple stimulation which has been known to make males lactate. There are also several types of medication which can cause increase of breast tissue and lactation in men as side effects.


When your body is fatigued after intense exercise it is because you are building up your muscle?

No. It is caused by the lactic acid build up in the muscle tissues. The symptoms include a burning feeling in your muscles, cramps, nausea , weakness, and feeling exhausted. A slower exercise will actually build more muscle.It's your body's way to tell you to stop what you're doing. When you exercise, your body uses oxygen to break down glucose for energy. During intense exercise, there may not be enough oxygen available to complete the process, so a substance called lactate is made. Your body can convert this lactate to energy without using oxygen.But this lactate or lactic acid can build up in your bloodstream faster than you can burn it off.The point when lactic acid starts to build up is called the "lactate threshold."