How is the ignition module? PO300 is a multiple misfire code. It can have many different causes. Coil being one of them. The 4.3 motor that you probably have is susceptible to the (sometinmes called: octapus or spider) fuel injection unit that set on top on the engine. I believe there was also a poppit valve problem on them. Do rule out basics like spark plug or ignition wire or poor connection at the coil from corrosion. you have to reset the computer and see if it still comes on then check the injectors
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