How does acetylcholine induce a decrease in heart rate?

Answer 1

Yes it does. Acetylcholine decreases the heart rate. It acts on the muscarinic (m2) receptor which decreases the activity of adenylate cyclase. This in turn decreases the production of cycliac AMP -> decreases the amount of protein kinase a activated -> decreases the amount of calcuim entry -> decreased activity of myocytes in heart- which results in decreased permeability of l type voltaged gated calcuim channels and decreases the length of time they are open for -> decreased calcuim levels -> decreased heart rate.

Answer 2

ACh is the primary neurotransmitter of the parasympathetic autonomic nervous system Acetylcholine (ACh) is released from the vagus nerve endings, and binds to muscarinic receptors on the pacemaker cells. The mechanism for binding is as follows: In the pacemaker cells, ACh acts on M2 Gi-protein coupled receptors. The βγ subunit of the G-protein activates potassium channels. These open causing potassium ions to leak out, and the cell becomes hyperpolarised (more negative). The funny current is also reduced by ACh. This is due to the inhibition of adenylate cyclase and the resultant decrease in cytosolic cAMP concentration. The decrease in cAMP directly decreases the activity of the ion channel, thus resulting in a decrease of sodium influx and it therefore takes longer for the cell to reach threshold. In addition, calcium influx is reduced; therefore, when threshold is reached depolarization takes longer. Thus the heart rate slows

Answer 3

BECause its aacetylcholine dont understant o what sily person