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Isoleucine is an amino acid. All amino acids contain an amine functional group, a, carboxylic acid functional group, and a side chain of varying nature. Since amines are generally basic, and carboxylic acids are obviously acidic, there is a self-neutralization of the two groups by themselves.

As a side note, the linking of the acid group of one amino acid to the base group of another is called a peptide bond, and is how amino acids are joined to form proteins.

Thus, the acidity or bascicity of a pure amino acid in solution is determined by the side chain. Since the side chain of isoleucine is a hydrocarbon (only C-H bonds) which is also neutral, a solution of isoleucine would be neutral as well, with a pH of around 7.

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