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The relationship between nucleotide sequence and amino acid sequence is called the genetic code.

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In those segments of DNA that carry information about proteins, the sequence of the nucleotides determines the sequence of amino acids in a polypeptide chain (one chain of a protein).

A group of three consecutive nucleotides codes for (represents) one amino acid. This group is called a codon.

The different amino acids are coded for by different codons. What each of the 64 codons stands for is the genetic code.

Three of the codons mean STOP; each of the 61 others stands for one of the 20 amino acids. In addition, one of the codons does double duty: it means START when it appears in a particular position.

The coding sections of DNA are called genes. Some genes code for RNA (such as transfer and ribosomal RNA); polypeptide chains are coded for by other genes, or, more specifically, exons of those genes. The exons are often separated by introns, which, although consisting of a sequence of nucleotides, do not code for amino acids.

The idea that nucleotide sequence (often referred to as base sequence) might code for amino acid sequence followed the proposal of the double-helix structure for DNA in 1953.

In 1958 Francis Crick gave the name sequence hypothesisto the idea that the nucleotide sequence corresponded to the sequence of amino acids in the chain to be synthesized. (For some reason this name is not well known now, and is often confused with Crick's term "central dogma", which, as Crick used it, denotes a different concept.)

In 1961 there were two important breakthroughs. Crick and Sydney Brenner showed that the code consisted of "triplets" (Brenner coined the word codon the following year), and Marshall Nirenberg and Heinrich Matthaei developed a technique for working out the code (in its messenger RNA version).

By 1966 all the 64 possible codons had been worked out.

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16y ago

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