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The first to seek new sea routes to the Indies and the Orient were primarily European explorers during the Age of Exploration in the late 15th century. Notable figures include Portuguese explorers like Prince Henry the Navigator, who advanced maritime knowledge, and Vasco da Gama, who successfully reached India by sailing around Africa. Additionally, Christopher Columbus, sailing under the Spanish flag, sought a westward route to Asia, ultimately leading to his discovery of the Americas in 1492. These explorations significantly expanded European trade networks and knowledge of the world.

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