Demyelinating diseases such as Multiple Sclerosis, Krabbe's Disease, and Guillain-Barre Syndrome involve degeneration of the myelin sheath. In these conditions, movement is limited to minimal as nerve conduction is reduced due to the loss of efficacy of the myelin.
MS
The reason for the destruction of myelin in GBS is unknown, although it is thought that the underlying problem is autoimmune in nature
The autoimmune disease that results in the destruction of myelin sheaths is called multiple sclerosis (MS). This condition leads to disruption in the transmission of signals along the nerves, causing a range of symptoms including weakness, numbness, vision problems, and difficulties with coordination and balance.
I think that with the destruction of myelin (produced by Oligodendrites in the CNS or the Schwann cells in the PNS that are glial cells that speed up the signal), the signal will be slower or even lost.
Muscular sclerosis is hardening and degeneration of the myelin sheath. Muscular sclerosis Multiple sclerosis is a disorder marked by destruction of the myelin sheath on neurons in the CNS and replacement with hard scar tissue.
Metachromatic leukodystrophy is a rare genetic disorder that affects the central nervous system, leading to the breakdown of myelin. Symptoms may include muscle weakness, cognitive decline, and vision and hearing loss. Without treatment, it can result in severe disability and premature death.
Adrenomyeloneuropathy is a progressive, X-linked, neurological disorder which deteriorates the myelin sheath which protects the spinal cord.
The disease affects the myelin sheath, which coats nerve cells. It causes progressive muscle weakness and paralysis
A disease that effects the myelin sheath is multiple sclerosis (MS). The function of the myelin sheath is to act as an insulator for the nerve cell. It's kind of like the rubber casing found on the outside of wires to protect the electron movement inside and allow us not to get shocked. MS causes the destruction of the myelin sheath which causes it to scar and harden and as a result we short circuit in our body. This is equivalent to peeling off some of the rubber casing off a wire and then plugging the wire into a socket. Some results of MS are: -double vision -speech impairment -jerky limbs -paralyzed muscles.
The myelin sheeth helps keep signals (like electrical impulses) within the axon so that they can get to the cell body (of the neuron). This is necessary for muscles to contract (to move). If myelin is lost the signal or "electrical impulse" is less and less which has an affect on muscle function because there isn't enough signal to stimulate or "tell" the muslce to move.
Progressive multifocal leukoencephalopathy (PML) is a neurological disorder characterized by destruction of the myelin, an oily substance that helps protect nerve cells in the brain and spinal cord, also known as central nervous system (CNS) white matter. PML occurs in approximately one in 200,000 people.
Gaps in the myelin sheath can result in reduced conduction velocity of nerve impulses, leading to impaired communication between neurons. This can manifest as symptoms such as weakness, numbness, and coordination issues. Conditions like multiple sclerosis can cause damage to the myelin sheath, resulting in these gaps.