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Considering Charles V ruled over Spain (and it's possessions in the New World) and the Holy Roman Empire (today Belgium, the Netherlands, Germany, Czech Republic, northern Italy, and Austria) in a time when the only way to send a message was by a messenger on a horse that could at best travel perhaps 40 miles a day, this prevented any serious centralized government from ruling.

Charles V had to rely on local authorities who often had very different rules and privileges he had to respect, as well as their own competing interests, distance made governance even harder. He also faced military challenges from the French, Turks, and even his own subjects (Protestants in Germany, the Communeros in Spain etc.).

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