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In the greatest way, it was when the ottoman empire finally conquered Eastern Roman Empire (Byzantines) all the men of science, art, and learning fled to the west (primarily Italy) along with many refugees. With their learning they sparked the Renaissance establishing European cultures as the most advanced and powerful for centuries to come. In addition Rome (Byzantines as the were in fact Rome) shielded the greater part of Europe from mongol and ottoman invasion for centuries allowing Western culture to form with out being smothered by barbarians or religious zealots with huge armies. They probably did help in many more ways than these, but these are probably most important

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