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In what two ways could morphine inhibit the the enzyme that breaks down acetecholine?
Enzyme-activity studies on acetylcholinesterase (AChE), the enzyme that is responsible for hydrolyzing acetylcholine (ACh), in the presence of opioids date back to the 1940s.
AChE inhibition by opioids has been suggested to be partly competitive and partly non-competitive(1, 2). Competitive inhibition would imply that that opiods compete with ACh for AChE, while non-competitive inhibition could mean that opioids bind to non-ACh binding regions on AChE and inactivate the part that hydrolyzes ACh.
Because AChE can still hydrolyse ACh in the presence of opioids the inhibition is only partial. This would make opioids partial competitive and partial non-competitive antagonists of AChE. Its unlikely that inhibition is biologically meaningful, however (3).
1. Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 375-385, 1943
2. Journal of Biological Chemistry, Vol. 138: 597-602, 1941
3. Clinical and Experimental Pharmacology and Physiology,Vol. 13, Issue 2, 159-162, 1986
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