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Pepsin is a proteolytic enzyme that primarily consists of a single polypeptide chain folded into a specific three-dimensional structure. Its active form is a globular protein, characterized by a compact arrangement of alpha-helices and beta-sheets. The enzyme features an active site that facilitates the hydrolysis of peptide bonds in proteins, making it essential for digestion in the acidic environment of the stomach. Pepsin is produced as an inactive precursor, pepsinogen, which undergoes activation through cleavage of specific peptide bonds.

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1mo ago

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Pepsin works best at pH 2 because it is an enzyme involved in digesting proteins in the stomach, where the pH is low due to the presence of hydrochloric acid. The acidic environment helps to activate pepsin and maintain its optimal structure for protein digestion.


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