Huntington's Disease

It is a disease where the body can't digest gluten. Gluten is commonly found in wheat and other products. A person eating gluten can experience bloating, upset stomach, gastric pain, vomiting, diarrhea.

Several reasons. Until a few years ago, there WAS no genetic screening possible for HD- only when symptoms developed could the disease be diagnosed. Symptoms typically appeared between 30-40 years of age- AFTER people had already had children. As a result, a new generation of Huntington's patients would be born before the parents knew that THEY had HD.

Chronic anger or anger-related lifestyle factors can contribute to a range of health issues such as high blood pressure, heart disease, weakened immune system, and increased risk of stroke. It can also negatively impact mental health, leading to anxiety, depression, and unhealthy coping mechanisms like substance abuse.

Endocrine diseases can be caused by various factors, including genetics, autoimmune conditions, tumors affecting the endocrine glands, infections, and lifestyle factors such as diet and exercise. Hormonal imbalances, disruptions in feedback loops, and malfunctions in specific endocrine glands can also lead to endocrine diseases.

Hungtington disease is a trinucleotide repeat genetic disorder, in which you have extra repeats of CAG in your gene coding for the hungtin protein. If you have more than 35 repeats you get the phenotype (symptoms), and it shows anticipation, which means that as the disease is passed on from generation to generation the repeats increase, hence the severity of the disease. It is quite rare, but the exact incidence is hard to estimate, because people carrying 30 repeats are asymptomatic. Hope this helps

Around 1 in 10,000 people are estimated to develop Huntington's disease, a rare genetic disorder. It is caused by a mutation in the HTT gene on chromosome 4.

It can be, especially for the family.

Yes. Most individuals afflicted with Huntington's Disease die prematurely, due to the progression of the disease.

Because Huntington's is a genetic disorder and it is known what sequence in what region causes the disorder.

No. Hemophilia is the result of any of a number of mutations such as reversals, translations, deletions, etc. These mutations need to have occurred in a very specific segment of the coding found on the X chromosome. The replication of that X chromosome however is unaffected with the exception that the mutation on it is replicated as well.

First, since this is a genetic disease, that is transmitted only by inheritance, a determination of family history of HD is usually made. There are also characteristic symptoms that become noticeable in later life, most commonly chorea- or uncontrolled movements of the body. In recent years, a genetic test has been developed that permits screening the the chromosome that causes HD- if you do not have that chromosome, you do not have, and will not develop HD. If you DO have that chromosome, at some point the symptoms of HD will develop. The exact age varies from one person to another. There is additional information at the website of the Huntington's Disease Society of America.

Yep- people who had a parent with HD. Since it is a genetic disease, that is the only way to get it- inherit it from a parent. Since it is inherited, there will be areas that have more cases- notably England, Australia, and Venezuela.

Disorders of the _________result in either too much or too little movement, as exemplified by Huntington's disease and Parkinson's disease

Yes. For example if cancer if very common in your family, you likely have genes that are more susceptible to it. That's why people say "its hereditary." It means its caused by your genes. If this is hereditary for you, you are more likely to die from cancer.

Huntington's is a genetic disease meaning that it is inherited to offspring of effected parents. If one of your biological parents have it you are at risk. I would ask my doctor for genetic testing to see if I had it.

A very, VERY personal decision. A person that has a parent that has Huntingtons, and is now an adult, might decide to be tested for HD prior to having children, or to help plan what they want to do in life. At present, there is no cure and limited treatment for Huntingtons. Some people may not WANT to know that they have a disease that is ultimately fatal, and has no cure. My wife has HD, and we have 4 adult children. Three of them decided to be tested- one decided not to.

It is a familial disorder that is genetic, and causes degeneration of some of the nerve cells in the brain. You inherit it from your parents.

The defect is in the HD gene (an inherited unit which contains a code for a protein), which is located on the short arm of chromosome 4.

The age at which the SYMPTOMS of HD appear varies. For MOST people, it is during their 30s-40s. With some people, it is older. There are a very few cases of juvenile HD, where the symptoms appear with children a few years old- but that is extremely rare.

Yes, Huntington's disease is a central nervous system disorder.

Huntingtons is a genetically inherited disease from a parent. when chromosomes are passed onto a child, the child wont always receive the chromosome containing the gene. But, if they do inherit the gene they will have the disease no matter what, because the disease is dominant. If it was recessive, the child could inherit the disease but not necessarily get the disease.

The neurotransmitter that has been thought to be deficient is enkephalin. The striatal neurons in the caudate and putamen degenerate, causing decrease release of enkaphalin, leading to decreased activity of the indirect pathway of the basal ganglia. There is decreased inhibition on the globus pallidus externus, leading to increased inhibition of the subthalamic nulceus. This inactivates the indirect pathway, leading to hyperkinetic movements.

Becasue HD is carried on a dominant gene. Unlike recessive gene diseases, where you would have to inherit the gene from BOTH parents, with a dominant gene disorder- well, you will inherit one of two genes from the parent with HD. One carries HD, the other does not. Odds are 1 out of two, or 50%. For each child born to that parent.

Huntington's disease is caused by a dominant allele

Depends on what stage of the disease has been reached. Up until symptoms appear, life is the same as for anyone else. As the symptoms increase, the person will have difficulty with movement, appear to be clumsy, spill or drop things. Their walk will become unsteady, and speech slurred- they may appear to be intoxicated- a problem when dealing with law enforcement officers. Problems with swallowing and choking are common, as are falls. Persons will also have problems with memory, reasoning, and be subject to irrational angry outbursts.