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Describe how the mutation has affected the protein coded by the gene?
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How can a point mutation alter the final structure of a protein?
In a point mutation, one nitrogen base is substituted for the correct base. Since most amino acids can be coded for by more than one codon, there may be no consequence to this mutation. However, sometimes a point mutation results in an incorrect amino acid being added to the amino acid sequence of the protein. This can cause a change in the shape and therefore function of the protein, which can be a harmful mutation. Two genetic disorders caused by a point mutation are cystic fibrosis and sickle cell anemia.
What codes for a protein in a eukaryote?
The mRNA is coded by the tRNA to make a protein.
If a strand of DNA with the sequence TGA mutated to GCA would it be a silent or missense mutation?
Both a silent and missense mutation is a change in one nucleotide. However, a silent mutation still codes for the same amino acid, but a missense mutation codes for a different amino acid. This means that a silent mutation will have no affect on the resulting protein, but a missense mutation will. Still, it is not guaranteed that a a missense mutation will result in a disfunction of created protein, as long as it is not occurring in the activation site.
Will the protein coded by the mutated strand of DNA function differently from the original strand?
It depends on the particular mutation. Some are "silent" which means the substitution of a base actually codes for the same amino acid as the previous. In this case, the sequence and function of the polypeptide is exactly the same. If the mutation is a nonsense or missense mutation however, then the structure and function of the protein is indeed affected. A nonsense mutation results in a codon becoming a "stop" codon, thereby terminating the polypeptide prematurely. Such proteins are nonfunctional. Missense mutations result in the change in sequence of amino acids; one amino acid takes the place of another due to the changed codon. These proteins can also be non-functional, but sometimes they can function, albeit less efficiently.
Contains a coded message of how to construct a protein?
tRNA
What would likely prevent DNA from producing the proteins coded by a gene?
A genetic mutation may prevent DNA from producing the protein coded by a gene.
Is a mutation dangerous?
Can be, but most mutations are neutral. If you had a gene that coded for a hydrophobic amino acid and it was point mutated to another gene that coded for another hydrophobic amino acid then there would be no change in the protein fold and no danger. Statistically this the the majority of mutation cases.
How can a point mutation alter the final structure of a protein?
In a point mutation, one nitrogen base is substituted for the correct base. Since most amino acids can be coded for by more than one codon, there may be no consequence to this mutation. However, sometimes a point mutation results in an incorrect amino acid being added to the amino acid sequence of the protein. This can cause a change in the shape and therefore function of the protein, which can be a harmful mutation. Two genetic disorders caused by a point mutation are cystic fibrosis and sickle cell anemia.
How are substitution mutations caused?
A substitution mutation in genetics is where one of the nucleotide bases of DNA is swapped for another. These mutations may or may not affect the protein that is being coded.
What amino acid is coded for by this sequences after mutation?
hahaqhaq
What amino acid is coded for by this sequence before mutation?
The neutral mutation does not change the amino acid coded for by the codon. A good example is the RNA codon that could be the CCA, CCC or the CCG.
What amino acid is coded for by this sequence before the mutation?
The neutral mutation does not change the amino acid coded for by the codon. A good example is the RNA codon that could be the CCA, CCC or the CCG.
What are the bases of mRNA coded for by this section of DNA before the mutation?
CAG
What happens if only one amino acid is coded incorrectly?
If an amino acid is coded incorrectly, then it would change the entire structure of the DNA and could possibly cause a mutation
What codes for a protein in a eukaryote?
The mRNA is coded by the tRNA to make a protein.
If a strand of DNA with the sequence TGA mutated to GCA would it be a silent or missense mutation?
Both a silent and missense mutation is a change in one nucleotide. However, a silent mutation still codes for the same amino acid, but a missense mutation codes for a different amino acid. This means that a silent mutation will have no affect on the resulting protein, but a missense mutation will. Still, it is not guaranteed that a a missense mutation will result in a disfunction of created protein, as long as it is not occurring in the activation site.
When geneticists speak of mutation they are referring to?
In genetics, mutation refers to a change in the sequence of genes. This can mean a change in the genes in an organism's DNA or in the DNA/RNA of a virus. There are many different types of mutations, which will have differing effects depending on how many bases/sections have been changed, where the sections are located and how different the resultant protein(s) will be. For example; a change in one base, that does not change the amino acid that will be coded for is called a silent mutation. This will have no affect on the resulting protein or the organism.
