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Reuptake - process by which neurotransmitters are taken back into the synaptic vesicles.
In a process called reuptake, they are reabsorbed by sending the neuron and recycled.
Neurotransmitters would continue to bind and rebind with the postsynaptic receptors, which would continue induction of a signal in the postsynaptic neurons, which would repropagate the initial signal. The case in drugs that block reuptake transporters (such as in serotonin reuptake inhibitor and norepinephrine reuptake inhibitor antidepressants, and dopamine reuptake inhibition found with cocaine and methylphenidate). This is also seen in cases where drugs block the breakdown of neurotransmitters at the synapse: - monoamine oxidase inhibitors (MAOIs) - Nardil, Parnate, selegiline - which prevent the breakdown of serotonin, norepinephrine, and dopamine - acetylcholinesterase inhibitors (AChE inhibitors) - organophosphase pesticides, nerve gas, racetams
Oh boy, that one is a doozy. There are anti-epileptics, tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), opiates, opiate receptor antagonists, dopamine agonists, dopamine antagonists and other antipsychotics, antiadrenergics, anticholinergics, and antibiotics -- just to name a few. Within each family of drugs above, there are a whole host of drug classes, which then are broken down into specific drugs. The list is a long one.
Some neurotransmitter molecules have a molecular structure that precisely fits the receptor site on the receiving neuron, much as a key fits a lock. When the agonist molecule excites, it is similar enough in structure to the neurotransmitter molecule that it mimics its effects on the receiving neuron. Morphine, for instance, mimics the action of endorphins by stimulating receptors in brain areas involved in mood and pain sensations. This antagonist molecule inhibits. It has a structure similar enough to the neurotransmitter to occupy its receptor site and block its action, but not similar enough to stimulate the receptor.
REUPTAKE
Unused neurotransmitters are absorbed :)
reuptake
reuptake.
reuptake is inhibited
Reuptake
Reuptake - process by which neurotransmitters are taken back into the synaptic vesicles.
In a process called reuptake, they are reabsorbed by sending the neuron and recycled.
In a process called reuptake, they are reabsorbed by sending the neuron and recycled.
Reuptake, or re-uptake, is the reabsorption of a neurotransmitter by a neurotransmitter transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse.Reuptake is necessary for normal synaptic physiology because it allows for the recycling of neurotransmitters and regulates the level of neurotransmitter present in the synapse and controls how long a signal resulting from neurotransmitter release lasts. Because neurotransmitters are too large and hydrophilic to diffuse through the membrane, specific transport proteins are necessary for the reabsorption of neurotransmitters. Much research, both biochemical and structural, has been performed to obtain clues about the mechanism of reuptake.
most neurotransmitters are not actually broken down, rather they are actively transported back into their pre release vesicles (this is called reuptake). Some neurotransmitters are broken down by a specific enzyme into non active parts i.e acetylcholine broken down by acetylcholinestarase
They can act in a number of ways, both presynaptically and postsynaptically. They can affect how vescicles release neurotransmitters, how neurotransmitters are cleaved/reuptake, they can block receptors, destroy receptors, agonistically bind to receptors which mimics the neurotransmitter. These are a few.