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How can a proto oncogene be converted into an oncogene without a change or mutation in its coding sequence?
Wiki User
∙ 12y ago
It could happen in three main manners: 1) the formation of multiple copies of the gene (duplications) that increase the expression of the gene 2) the mutation happens in the promoter of the gene or in others non coding regions causing an increase in the level of the mRNA of the gene 3) it could happen a translocation that put the gene under an active promoter (bcl2 in lymphomas) , or brings to the formation of a chimaeric gene (the philadelphia chromosome in leukemia)
Wiki User
∙ 15y ago
Wiki User
∙ 12y agoDue to the effects of Epi-Genetics, for one.
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What this the relationship between DNA mutation and cancer?
because your climbing near the sun and the sun gives you skin cancer....
What causes random mistakes to occur in a DNA sequence?
There is a reason why random mistakes occur. The genes themselves carry a code for mutation which is expressed randomly without generational continuity. It may be considered recessive in the extreme. The ability for random mutation to "test out" new designs is at the very core of Darwinian evolution. These mistakes are supposed to happen. If they did not happen we would not be sharing this very info with each other as we would not exist.
What is converted nouns?
A converted noun is a noun that has been converted from one grammatical form to a word of another grammatical form without any changes to spelling or pronunciation. Noun conversion is also called 'zero derivation'. An example of a converted noun is march: The march was long and difficult. Without changing the spelling or pronunciation, it is also a verb: You will march to your room young man!
What is 1670 cm3 converted into Kg?
You cannot convert a volume into a mass without knowing the substance/material and its density.
Why is XI clotting factor absent?
If the question is; what causes factor XI deficiency, also known as Hemophilia C, the answer is in the genetics of the individual. The gene sequence for the production of the factor XI protein in not on the X chromosome as it is with Hemophilia A and B. This means that Hemophilia C equally common in males and females alike. (If 1 in 100,000 can ever be considered common.) Since the route cause of Hemophilia C is genetic, it is most often inherited from the parents. In communities such as people of Ashkenazi Jewish decent, the disorder is more common than in mass population. Due to their beliefs, they have practiced intermarrying which has increased the likelihood of the mutation being passed on. Combine this with the fact that the mutation for factor XI deficiency is a dominant trait, the disorder is easily passed generation to generation. Of course there is always a chance that the mutation takes place at the time of conception or shortly thereafter and is not inherited from a parent. As for the actual production of the factor protein molecule not being produced or being produced incorrectly, we have to take a closer look at the genetic sequence. In a person without the deficiency, when the body needs more factor XI, the genetic sequence that encodes the production of the protein molecule becomes RNA and acts like a factory, producing the protein on a production like. As the molecules move along the RNA structure, different pieces of the molecule are added and it moves to the next step in production. If one of the manufacturing steps is being preformed incorrectly or never sends the molecule farther down the assembly line, the molecule never gets completed correctly. This is the case when a mutation in that specific sequence occurs, leading to the factor deficiency.
What One example of a mutation that would not affect an organisms phenotype?
A Missense Mutation.It is a point mutation where the mutations alters the base sequence without changing the resulting function of the subsequent protein. This is usually when the mutation does not change the amino acid which the codon codes for.
Why is mutation important to spectation?
Without mutation there can be no evolution. Without evolution there can be no speciation.
Why it is important for a cell to copy DNA without making mistake?
It is important for cell to copy DNA without making mistake because the DNA contain genetic code in the form of nucleotide base pair sequence, if those sequence get wrong then the DNA code for wrong gene i.e. there will be a mutation which can be lethal or dangerous.
What this the relationship between DNA mutation and cancer?
because your climbing near the sun and the sun gives you skin cancer....
What is a harmful mutation?
a mutation is sometimes a form of adaptation, but if something changes in the DNA of the species and could possibly be harmful to it, that is a harmful mutation.Examples:-born without a part of the brain-cancer is a form of a harmful mutation-hypoglycemia
What causes random mistakes to occur in a DNA sequence?
There is a reason why random mistakes occur. The genes themselves carry a code for mutation which is expressed randomly without generational continuity. It may be considered recessive in the extreme. The ability for random mutation to "test out" new designs is at the very core of Darwinian evolution. These mistakes are supposed to happen. If they did not happen we would not be sharing this very info with each other as we would not exist.
The number which best completes the sequence below is 76.400 76.004.77.000 77.400?
We can't answer this accurately without knowing the sequence.
What is the next number in the sequence numvers of 6?
Without a sequence given in the question, the next number to 6 is 7.
Can Any photo converted into without cloth?
yes
What is the nth term for -3052?
A single number, such as -3052 cannot define a sequence and, without a sequence you cannot have an nth term.
What is the rule for this pattern 2 6 8 14?
Without further terms in the sequence, it is impossible to determine what the rule in the sequence is.
Describe 4 ways mutation can occur without change its phenotype?
The phenotype will not be affected with silent mutation and synonymous mutation. It also can be mutated in a coding region that changes the amino acid or changes the protein to be folded.
