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The top ten cities by population in what the U.S. Census Bureau defines as the Midwest Region of the U.S., based on their July 2011 estimates, are...

  1. Chicago, Illinois (2,707,120)
  2. Indianapolis, Indiana (827,609)
  3. Columbus, Ohio (797,434)
  4. Detroit, Michigan (706,585)
  5. Milwaukee, Wisconsin (597,867)
  6. Kansas City, Missouri (463,202)
  7. Omaha, Nebraska (415,068)
  8. Cleveland, Ohio (393,806)
  9. Minneapolis, Minnesota (387,753)
  10. Wichita, Kansas (384,445)
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10y ago
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11y ago

The four largest cities in the Midwest U.S.A are:

  • Chicago
  • Detroit
  • Indianapolis
  • St.Louis

The 2010 U. S. Census revealed a change to the previous answer.

Here are the top ten based on U. S. Census Bureau 2011 estimates:

  1. Chicago, Illinois (2,707,120)
  2. Indianapolis, Indiana (827,609)
  3. Columbus, Ohio (797,434)
  4. Detroit, Michigan (706,585)
  5. Milwaukee, Wisconsin (597,867)
  6. Kansas City, Missouri (463,202)
  7. Omaha, Nebraska (415,068)
  8. Cleveland, Ohio (393,806)
  9. Minneapolis, Minnesota (387,753)
  10. Wichita, Kansas (384,445)
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13y ago

1. Chicago

2. Detroit

3. Indianapolis

4. St. Louis

5. Minneapolis

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12y ago

well these arn't the cities but they are the states:

Kansas, Missouri, North Dakota, South Dakota, Wisconsin, Michagan, Ohio, Illinois, Iowa, Minnisota, Navada, and Indiana

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14y ago

Chicago

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11y ago

Chicago, Illinois.

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8y ago

Missouri

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9y ago

j

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Q: What are the 5 largest cities in the Midwest Region?
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