What is the best drive route from Boston to Indianapolis?

Answer 1

1. Take I-69 NORTH from northeastern Indianapolis to I-80/90 TOLL ROAD towards Chicago and TOLEDO at EXIT 156. You want I-80/90 TOLL ROAD EAST towards TOLEDO.
2. Take I-80/90 TOLL ROAD into Ohio where it becomes the Ohio Turnpike (toll).
3. Continue on the Ohio Turnpike to I-480 EAST towards CLEVELAND at EXIT 156.
4. Take I-480 EAST to I-271 NORTH towards ERIE, PA at EXIT 26. Stay left and go onto I-271 NORTH EXPRESS LANES TO I-90 towards ERIE, PA
5. Take I-271 NORTH EXPRESS LANES to I-90 EAST towards ERIE, PA.
6. Take I-90 EAST through Ohio and Pennsylvania into New York where it becomes the New York State Thruway.
7. Take the New York State Thruway EAST along I-90 and then SOUTH along I-87 to EXIT 21A. This will be the exit TO I-90 EAST to Massachusetts TURNPIKE towards BOSTON.
8. Once you are on I-90 EAST, continue on I-90 EAST on the Massachusetts Turnpike to Boston.