route 66
The best route for driving from Indianapolis to Washington DC is to take Interstate 70 East to Interstate 270 South, then merge onto Interstate 495 East which will take you directly into Washington DC. This route is approximately 600 miles and takes about 9-10 hours depending on traffic and weather conditions.
Take I-90 EAST to Boston
Fly
E842 is the best route across. SS16 to A14 connects to that.
The best route to drive from Chicago to Pittsburgh is to take Interstate 90 East to Interstate 80 East. This route is the most direct and efficient way to reach Pittsburgh from Chicago by car.
Personally I'd probably use the I-80 route.
a popular cattle drive route in the years after the Civil War
The quickest and shortest route is I-5 North.
The best route for a drive from Salt Lake City to Denver is typically via Interstate 80 East and Interstate 25 South. This route is the most direct and commonly used for traveling between the two cities.
I-71 South to Columbus, then I-70 West through Indianapolis and on to St. Louis.
Take HIGHWAY 102 NORTH to (TRANS-CANADA) HIGHWAY 104 WEST to AMHERST and NEW BRUNSWICK at EXIT 15W.Take the TRANS-CANADA HIGHWAY on HIGHWAY 104 in Nova Scotia and on ROUTE 2 in New Brunswick to ROUTE 95 TO I-95 to WOODSTOCK and HOULTON, ME at EXIT 188.Take ROUTE 95 to I-95 SOUTH in Houlton, Maine, U.S.A. Continue straight on I-95 SOUTH to Boston.