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It depends on the substance. Remember that moles are a unit of amount, and one mole is 6.02 × 1023 atoms. So if you have lead and hydrogen, they are obviously going to weigh differently. It would take far fewer atoms of lead to amount to 1 gram; therefore, less moles. However, one hydrogen atom has far less mass than one lead atom, and would need more atoms (and moles) to make one gram.

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