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Bioavailability of a drug is the amount of the drug that is available for use by the body after it has been metabolised by the liver.
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How route of administration drug can control bioavailability drug?
biovability of intral nasal route
Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
yes
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
What is mineral bioavailability?
The proportion of the mineral that can be utilised
Pharmaceutical importance of carbohydrates?
The pharmaceutical importance of carbohydrates cannot be overstated, as these organic compounds play crucial roles in various aspects of drug formulation, delivery, and efficacy. Despite often taking a backseat to proteins and fats in discussions of pharmaceuticals, carbohydrates are indispensable components with unique properties that pharmaceutical scientists leverage to enhance therapeutic outcomes. One primary role of carbohydrates in pharmaceuticals is as excipients in drug formulations. Excipients are inert substances added alongside active pharmaceutical ingredients (APIs) to facilitate drug delivery, stability, and bioavailability. Carbohydrates serve as bulking agents, fillers, and stabilizers in dosage forms such as tablets, capsules, and suspensions. They contribute to the physical properties of the formulation, ensuring uniformity, flowability, and compressibility. Moreover, carbohydrates are instrumental in controlling drug release kinetics, enabling sustained, controlled, or targeted drug delivery. By modulating the rate and extent of drug release, carbohydrates influence the pharmacokinetics and pharmacodynamics of drugs, optimizing therapeutic efficacy while minimizing adverse effects. In addition to their role in conventional dosage forms, carbohydrates are integral components of novel drug delivery systems. These systems, such as liposomes, microspheres, and nanoparticles, offer advantages such as targeted drug delivery, sustained release, and enhanced bioavailability. Carbohydrate-based matrices provide structural integrity and biocompatibility to these delivery systems, facilitating their application in diverse therapeutic areas. Furthermore, carbohydrates play a crucial role in parenteral formulations by serving as tonicity-adjusting agents to maintain isotonicity and osmolarity. This ensures patient safety and minimizes tissue irritation upon injection, making carbohydrates indispensable in injectable pharmaceutical products. Overall, the pharmaceutical importance of carbohydrates extends beyond their nutritional value to encompass critical functions in drug formulation, delivery, and efficacy. Their versatility, biocompatibility, and ability to modulate drug release kinetics make carbohydrates indispensable components in pharmaceuticals. As the pharmaceutical industry continues to evolve, further exploration of carbohydrate-based formulations and delivery systems holds promise for advancing drug development and improving patient outcomes.
What is bioavailability?
Bioavailability is the amount of drug which reaches the site of physiological activity after administration.
What is a bioequivalence?
A bioequivalent is a formulation of a drug which is equivalent to some other formulation in terms of bioavailability.
How route of administration drug can control bioavailability drug?
biovability of intral nasal route
Bio availabilty has a better feature when it gets dissolved or undissolved?
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html
Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
yes
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
What is the medical term meaning extent to which a drug or other substance becomes available to the body?
Bioavailability
What is bioenhancer?
A bioenhancer is a biological enhancer - any naturally-occurring compound which increases drug bioavailability.
What is a bioenhancer?
A bioenhancer is a biological enhancer - any naturally-occurring compound which increases drug bioavailability.
What factors determine a drug's rate of metabolism?
How quickly a drug clears from the body is a function of its absorption, bioavailability, distribution, metabolism, and excretion properties.
Why is a pharmaceutical equivalent not necessarily therapeutically equivalent?
They can still have different bioavailability (the amount of drug that is delivered to the site of action and the rate at whcih it is available). Pharmacetical equivalents do not have to have the same release mechanisms, and can therefore affect their bioavailability.
What is bioavilability in pharmacology?
Bioavailability in pharmacology refers to the fraction of a drug that reaches the systemic circulation and is available to produce an effect after administration. It is typically expressed as a percentage and takes into account how much of the administered dose is absorbed and becomes available to the body. Factors like drug formulation, route of administration, and first-pass metabolism can affect a drug's bioavailability.
