Topoisomerase: are isomerase enzymes that act on the topology of DNA
Helicase untwists the double helix and separates the template DNA strands at the replication fork. This untwisting causes tighter twisting ahead of the replication fork, and topoisomerase helps relieve this strain
It cleaves both strands of the DNA helix during DNA replication and transcription.
This relieves the torsional stress during DNA unwinding. After DNA has unwound, it helps reconnect (religate) the double stranded DNA, restoring the DNA chain integrity.
The function of topoisomerase is to unwind the helix of DNA into a regular, ladder-like shape. Topoisomerase is only found in primates. In other organisms, the molecule is called gyrase that unwinds the DNA.
This torsional stress is relieved by the enzymes DNA topoisomerases. Topoisomerases relieve torsional stresses in duplexes of DNA by introducing either double- (topoisomerases II) or single-stranded (topoisomerases I) breaks into the backbone of the DNA. These breaks allow unwinding of the duplex and removal of the replication-induced torsional strain. The nicks are then resealed by the topoisomerases.
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It's the relieving strand in the DNA ahead of the replication fork
Topoisomerases disattach and reattach DNA. It is required for DNA to reproduce>
What is the role of dna ligase during replication
Helicase unwind the two DNA strands while topoisomerase unwind and also rejoin the the two strands of DNA.
Topoisomerase is not a restriction enzyme but an enzyme that keeps unwound DNA from tangling while it is being replicated.
HaeIIIrestriction enzymes
It has to make two products, Those are ingredients of the dark reaction.
one of them is heliocase. it 'unzips' the DNA strand. You can always remember this because it's in a popular joke: Q. Why is the enzyme heliocase a lot like a teenage boy? A. They both want to unzip your jeans (genes) !!!!!
The topoisomerase enzyme uncoils the double helical structure of DNA during its replication to form the replication fork. In eukaryotes both posive and negative supercoils get unbind by topoisomerase I & II respectively.Topoisomerase isomerase unwinds DNA to form replication fork
Helicases and gyrases both function to uncoil the supercoiling of the two DNA strands. Moreover, gyrase is responsible for adjusting the tension in the two strands so that they don't snap while unraveling.
Leonardo Salmena has written: 'The cell cycle-dependent regulation of DNA topoisomerase II[alpha] expression is mediated by proteasomal degradation'
Helicase unwind the two DNA strands while topoisomerase unwind and also rejoin the the two strands of DNA.
Topoisomerase
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Topoisomerase 1
The genre of EverQuest II: The Shadow Odyssey is Role Playing.
The return of Charles II.
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