Well, let's say for instance Sydney to Santiago or Sydney to Buenos Aires
LAN Airlines flies Sydney - Santiago with a short stopover in Auckland, New Zealand
Aerolinas Argentinas flies Sydney - Buenos Aires nonstop on selected days
Probably by flying straight over Antarctica, though I'm not sure if there is any airline doing that.
The Panama Canal is the shortest route.
The shortest route between South America and Africa would have you leaving from the nation of Brazil. Brazil remained a Portuguese colony until 1808.
Take I-65 SOUTH to NASHVILLE.
I-95 South
-- Africa -- Oceania -- Australia -- South America
North America, South America, Australia, and Antarctica are the four continents without an Islamic State.
South America reaches further south than Australia.
wormhole
South America
464 miles. I-70 West to I-57 South to I-55 South
I-95 south to Jacksonville I-75 south to Tampa
South America.