Sickle-Cell Disease

It is important to note that sickle-cell anemia comes in two forms. The homozygous sickle-cell anemia and the heterozygous sickle-cell trait. The difference between the two is that sickle-cell anemia has a high rate death rate at a young age (20~), and the sickle-cell trait is nearly asymptomatic.

In regions such as North America, sickle-cell anemia would be selected against and would eventually leave the gene pool. The sickle-cell trait on the other hand, has little effect on the fitness of the organism, and as such will remain in the gene pool.

In malaria endemic regions such as sub-Sahara Africa, sickle-cell anemia provides very high levels of immunity to malaria and the sickle-cell trait provides a slightly lesser level of immunity. Both forms of sickle-cell will increase the organisms fitness and as such, it will remain in the gene pool. Further on, the sickle-cell trait has greater fitness than sickle-cell anemia, hence, the sickle-cell trait will be selected as the fittest allele.


If s is the sickle-cell allele and S is a normal allele;

The relative fitness in malaria endemic regions;
Ss > ss > SS
Sickle-cell trait > Sickle-cell anemia > Normal

The relative fitness in non-malaria endemic regions;
SS > Ss > ss
Normal > Sickle-cell trait > Sickle-cell anemia

the sickle trait possess a resistance to the infection of malaria.

Write a summary of the main ideas you covered in the essay.

The defect is that hemoglobin (the protein) elongates. Instead of being circular, it acquires a crescent shape. With this shape, its harder for it to absorb and release oxygen. Also, when the blood cell reaches the capillaries, it can't fit through as well as normal blood cells can, which is why Sickle-Cell is painful.

No. This is a genetically inherited disorder. It can not be "caught" in any way including sexually.
No, sickle-cell is a genetic abnormality not an STD (venereal disease is a somewhat out-dated term).

no

There are some people in the society who try to capitalize the chronic illnesses like the sickle cell anemia. But then they are the ones who take care of the children and not you.

Well, you can´t be white if you have interracial marriages in your ancestors, so the questions is quite illogical. But anyways a blood transfusion doesn´t have anything to do with what your children will inherit from your genes... for example, if you are a AB+ and receives a O- blood transfusion, it´ll have nothing to do with your future children, it´s impossible to a AB+ to conceive a O- child, and vice-versa.

20,000 people die with sickle cell each year

An antineoplastic drug (hydroxyurea) may prevent future episodes of priapism for patients with sickle cell disease.

www.cdc.gov

Sickle-cell disease (SCD), or sickle-cell anaemia or drepanocytosis, is an autosomal co-dominant genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape.

Painful crises, also known as vasoocclusive crises, are a primary symptom of sickle cell anemia in children and adults. The pain may be caused by small blood vessel blockages that prevent oxygen from reaching tissues.

Cells can cause disease, but can also prevent disease.

Miles Davis, Paul Williams, Tionne, and Georgeanna Tillman are famous celebrities that have or had sickle cell disease.

large red bump that looks like a pimple, small boils, do not pick! go to the doctor and have them do a staph culture. you can aslo see pics of staph online if you google "pictures of staph". staph is very dangerous in certain strains and also contagious. if you are certain it may be staph go get the culture asap.

because the sickle cell has small surface. and the ESR is proportional to surface area of red blood cell.

Children with sickle cell anemia may have delayed growth and reach puberty at a later age than normal

"Sickle cells" refers to an abnormal shape (rather like a sickle) of red blood cells. Red blood cells in humans do not have a nucleus.

every state in America know preforms a small blood test to detect sickle cell it wont cost you much,

one test is preformed to see if you have sickle cell if the hospital thinks you do they will call you in for another test to confirm dignoses.

but don't freak out sickle cell is a rare but serious disease.

hope this helped ^_^

.No he does not. He runs a foundation with his brothers catering to people living with the disease, primarily children.

well no cancer can not be cured by sickle celled anemia because sickle cell is the abnormalty of the shape of the cell.

because people in europe have not gotten used to sickle cell anemia because it is soo rare in europe

Hemoglobin