Sickle-Cell Disease

If one represents a sickle cell gene thus "C" and a normal gene thus "O" then both parents are:

Mum CO

Dad CO

The possibilities for their children are therefore

CC

OO

CO

CO

in those proportion so 1in 4 will have sickle cell anaemia, 2 in 4 will be carriers (like their parents) and 1/4 will be normal.

The replacement of bases in the DNA molecule that leads to sickle cell anemia is caused by a mutation, specifically a point mutation known as a missense mutation. In this case, the substitution of GAA (which codes for glutamic acid) with GTA (which codes for valine) alters the hemoglobin protein's structure, resulting in the characteristic sickle-shaped red blood cells. This change affects the oxygen-carrying capacity of the blood and leads to various health complications associated with the disease.

Sickle cell trait itself typically does not qualify a child for Supplemental Security Income (SSI) benefits, as it is generally considered a genetic condition that does not significantly impair functioning or result in severe health issues. SSI is designed for individuals with disabilities that severely limit their ability to work or perform daily activities. However, if a child with sickle cell trait experiences severe complications related to the condition, they may be eligible for SSI based on those specific health challenges. It's important to consult with a qualified professional for a thorough evaluation of the child's situation.

Sickle cell anemia can effect anyone who gets the disorder passed down from the parents. I believe it is a dominant disorder, meaning only one parents needs to pass it down.

Sickle cell disease symptoms include episodes of severe pain, known as sickle cell crises, due to blocked blood flow. Other common symptoms are anemia, fatigue, swelling in the hands and feet, frequent infections, and delayed growth in children. Individuals may also experience jaundice and vision problems. Symptoms can vary in intensity and frequency among those affected.

Sickle cell trait primarily affects red blood cells, not white blood cells. Individuals with sickle cell trait have one normal hemoglobin gene and one sickle cell gene, which can lead to the production of abnormal hemoglobin in red blood cells, causing them to assume a sickle shape under low oxygen conditions. While sickle cell trait can influence overall health and certain aspects of the immune response, it does not directly affect the quantity or function of white blood cells.

Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. The prevalence of the disease in the United States is approximately 1 in 5,000, mostly affecting Americans of Sub-Saharan African descent. In simplified terms usually black people.

it's caused by a mutation in the hemoglobin gene(a weird change that's basically in the red blood cell)disease is a group of genetic dis orders caused by sickle hemolobin(hgb s or hb s(

Sickle-cell crisis.