Bird Flu

Influenza (flu)

2009 flu pandemic (Swine flu) Virus Avian influenza Swine influenza Flu season Research Vaccine Treatment A/H5N1 subtype A/H1N1 subtype Pandemic

For the H5N1 subtype of Avian influenza see H5N1.

Avian influenza, sometimes avian flu, and commonly bird flu, refers to "influenza caused by viruses adapted to birds."^{[1][2][3][4][5][6][7]} Of the greatest concern is highly pathogenic avian influenza (HPAI).

"Bird flu" is a phrase similar to "swine flu," "dog flu," "horse flu," or "human flu" in that it refers to an illness caused by any of many different strains of influenza viruses that have adapted to a specific host. All known viruses that cause influenza in birds belong to the species influenza A virus. All subtypes (but not all strains of all subtypes) of influenza A virus are adapted to birds, which is why for many purposes avian flu virus is the influenza A virus (note that the "A" does not stand for "avian").

Adaptation is non-exclusive. Being adapted towards a particular species does not preclude adaptations, or partial adaptations, towards infecting different species. In this way strains of influenza viruses are adapted to multiple species, though may be preferential towards a particular host. For example, viruses responsible for influenza pandemics are adapted to both humans and birds. Recent influenza research into the genes of the Spanish flu virus shows it to have genes adapted to both birds and humans; with more of its genes from birds than less deadly later pandemic strains.

Genetics

Genetic factors in distinguishing between "human flu viruses" and "avian flu viruses" include:

PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a Lys.

HA: (hemagglutinin): Avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors. Hemagglutinin is the major antigen of the virus against which neutralizing antibodies are produced and influenza virus epidemics are associated with changes in its antigenic structure. This was originally derived from pigs, and should technically be referred to as "Pig Flu" (see ref. 7a)

Subtypes

There are many subtypes of avian influenza viruses, but only some strains of four subtypes have been highly pathogenic in humans. These are types H5N1, H7N3, H7N7 and H9N2.^[8]

Examples of avian influenza A virus strains:^[9]

Influenza pandemic

Pandemic flu viruses have some avian flu virus genes and usually some human flu virus genes. Both the H2N2 and H3N2 pandemic strains contained genes from avian influenza viruses. The new subtypes arose in pigs coinfected with avian and human viruses and were soon transferred to humans. Swine were considered the original "intermediate host" for influenza, because they supported reassortment of divergent subtypes. However, other hosts appear capable of similar coinfection (e.g., many poultry species), and direct transmission of avian viruses to humans is possible.^[10] The Spanish flu virus strain may have been transmitted directly from birds to humans.^[11]

In spite of their pandemic connection, avian influenza viruses are noninfectious for most species. When they are infectious they are usually asymptomatic, so the carrier does not have any disease from it. Thus while infected with an avian flu virus, the animal doesn't have a "flu". Typically, when illness (called "flu") from an avian flu virus does occur, it is the result of an avian flu virus strain adapted to one species spreading to another species (usually from one bird species to another bird species). So far as is known, the most common result of this is an illness so minor as to be not worth noticing (and thus little studied). But with the domestication of chickens and turkeys, humans have created species subtypes (domesticated poultry) that can catch an avian flu virus adapted to waterfowl and have it rapidly mutate into a form that kills in days over 90% of an entire flock and spread to other flocks and kill 90% of them and can only be stopped by killing every domestic bird in the area. Until H5N1 infected humans in the 1990s, this was the only reason avian flu was considered important. Since then, avian flu viruses have been intensively studied; resulting in changes in what is believed about flu pandemics, changes in poultry farming, changes in flu vaccination research, and changes in flu pandemic planning.

H5N1 has evolved into a flu virus strain that infects more species than any previously known flu virus strain, is deadlier than any previously known flu virus strain, and continues to evolve becoming both more widespread and more deadly causing Robert G. Webster, a leading expert on avian flu, to publish an article titled "The world is teetering on the edge of a pandemic that could kill a large fraction of the human population" in American Scientist. He called for adequate resources to fight what he sees as a major world threat to possibly billions of lives.^[12] Since the article was written, the world community has spent billions of dollars fighting this threat with limited success.

Vaccines have been formulated against several of the avian H5N1 influenza varieties. Vaccination of poultry against the ongoing H5N1 epizootic is widespread in certain countries. Some vaccines also exist for use in humans, and others are in testing, but none have been made available to civilian populations, nor produced in quantities sufficient to protect more than a tiny fraction of the Earth's population in the event that an H5N1 pandemic breaks out. The World Health Organization has compiled a list of known clinical trials of pandemic influenza prototype vaccines, including those against H5N1.

H5N1

H5N1

Influenza A virus subtype H5N1 Genetic structure Infection Human mortality Global spread in 2004, 2005, 2006, 2007 Social impact Pandemic

The highly pathogenic influenza A virus subtype H5N1 virus is an emerging avian influenza virus that has been causing global concern as a potential pandemic threat. It is often referred to simply as "bird flu" or "avian influenza" even though it is only one subtype of avian influenza causing virus.

H5N1 has killed millions of poultry in a growing number of countries throughout Asia, Europe and Africa. Health experts are concerned that the co-existence of human flu viruses and avian flu viruses (especially H5N1) will provide an opportunity for genetic material to be exchanged between species-specific viruses, possibly creating a new virulent influenza strain that is easily transmissible and lethal to humans.^[13]

Since the first H5N1 outbreak occurred in 1987, there has been an increasing number of HPAI H5N1 bird-to-human transmissions leading to clinically severe and fatal human infections. However, because there is a significant species barrier that exists between birds and humans, the virus does not easily cross over to humans, though some cases of infection are being researched to discern whether human to human transmission is occurring.^[10] More research is necessary to understand the pathogenesis and epidemiology of the H5N1 virus in humans. Exposure routes and other disease transmission characteristics such as genetic and immunological factors, that may increase the likelihood of infection, are not clearly understood.^[14]

On January 18, 2009, a 27-year-old woman from eastern China has died of bird flu, Chinese authorities said, making her the second person to die this year from the deadly virus. Two tests on the woman were positive for H5N1 avian influenza, said the ministry, which did not say how she might have contracted the virus^[15].

Although millions of birds have become infected with the virus since its discovery, 262 humans have died from the H5N1 in twelve countries according to WHO data as of August 31, 2009.^[16]

The avian flu claimed at least 200 humans in Indonesia, Vietnam, Laos, Romania, China, Taiwan, Turkey and Russia. Epidemiologists are afraid that the next time such a virus mutates, it could pass from human to human; however, the current A/H5N1 virus does not transmit easily from human to human. If this form of transmission occurs, another pandemic could result. Thus disease-control centers around the world are making avian flu a top priority. These organizations encourage poultry-related operations to develop a preemptive plan to prevent the spread of H5N1 and its potentially pandemic strains. The recommended plans center on providing protective clothing for workers and isolating flocks to prevent the spread of the virus.^[17]

In domestic birds

The current absence of highly pathogenic avian influenza (HPAI) in poultry in the United States is maintained through constant surveillance of poultry flocks in commercial poultry operations. Detection of a HPAI virus results in immediate elimination of the flock. Less pathogenic viruses are controlled by vaccination, which is done primarily in turkey flocks (ATCvet codes: QI01AA23 for the inactivated fowl vaccine, QI01CL01 for the inactivated turkey combination vaccine).^[18]

See also

Wikinews has related news: Six-year-old Egyptian boy contracts bird flu

• Influenza
• H5N1
• Global spread of H5N1
• Transmission and infection of H5N1
• Subtypes of Influenza A virus
• Influenzavirus A
• Influenza pandemic
• Influenza Genome Sequencing Project
• Influenza research
• Influenza vaccine
• OIE/FAO Network of Expertise on Avian Influenza
• International Partnership on Avian and Pandemic Influenza
• Pandemic Preparedness and Response Act

Notes

References

• Allegra, Ernesto P., ed. (2008), Avian Influenza Research Progress, Nova Publishers. Pp. 161, ISBN 160021617X, <http://books.google.com/books?id=Xl9GtrLkIx0C&printsec=frontcover&source=gbs_summary_r&cad=0>
• Bornholdt, Zachary A. & Venkataram Prasad (18 December 2008), "X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus", Nature 456: 985–988, <http://dx.doi.org/10.1038/nature07444>
• Boyce, Walter M.; Christian Sandrock & Chris Kreuder-Johnson et al. (2009), "Avian influenza viruses in wild birds: A moving target", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 275–286, <http://dx.doi.org/10.1016/j.cimid.2008.01.002>
• Brown, Lorena E. & Anne Kelsol (24 March 2009), "Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes", Immunology and Cell Biology Online: 1–9, <http://dx.doi.org/10.1038/icb.2009.16>
• Cardona, Carol J.; Zheng Xing & Christian E. Sandrock et al. (2009), "Avian influenza in birds and mammals", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 255–273, <http://dx.doi.org/10.1016/j.cimid.2008.01.001>
• Cattoli, Giovanni; Isabella Monne & Alice Fusaro et al. (2009), "Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Africa: A Comprehensive Phylogenetic Analysis and Molecular Characterization of Isolates", PLoS ONE 4 (3): e4842, <http://dx.doi.org/10.1371/journal.pone.0004842>
• Charlton, Bruce; Beate Crossley & Sharon Hietala (2009), "Conventional and future diagnostics for avian influenza", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 341–350, <http://dx.doi.org/10.1016/j.cimid.2008.01.009>
• Chen, L- M.; C. T. Davis & H. Zhou et al. (2008), "Genetic Compatibility and Virulence of Reassortants Derived from Contemporary Avian H5N1 and Human H3N2 Influenza A Viruses", PLoS Pathog 4 (5): e1000072, <http://dx.doi.org/10.1371/journal.ppat.1000072>
• Chen, Rubing & Edward C. Holmes (2006), "Avian Influenza Virus Exhibits Rapid Evolutionary Dynamics", Molecular Biology and Evolution 23 (12): 2336–2341, <http://dx.doi.org/10.1093/molbev/msl102>
• Dugan, V. G.; R. Chen & D. J. Spiro et al. (2008), "The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds", PLoS Pathog 4 (5): e1000076, <http://dx.doi.org/10.1371/journal.ppat.1000076>
• Escorcia, Magdalena; Lourdes Vázquez & Sara T. Méndez et al. (2008), "Avian influenza: genetic evolution under vaccination pressure", Virology Journal 5 (15), <http://virologyj.com/content/pdf/1743-422X-5-15>
• Fasina, Folorunso; Shahn Bisschop & Robert Webster (2007), "Avian influenza H5N1 in Africa: an epidemiological twist", The Lancet Infectious Diseases 7 (11): 696–697, <http://dx.doi.org/10.1016/S1473-3099(07)70244-X>
• Gaidet, N.; G. Cattoli & S. Hammoumi et al. (2008), "Evidence of Infection by H5N2 Highly Pathogenic Avian Influenza Viruses in Healthy Wild Waterfowl", PLoS Pathog 4 (8): e1000127, <http://dx.doi.org/10.1371/journal.ppat.1000127>
• Gultyaev, Alexander P.; Hans A. Heus & René C. L. Olsthoorn (2007), "An RNA conformational shift in recent H5N1 influenza A viruses", Bioinformatics 23 (3): 272–276, <http://dx.doi.org/10.1093/bioinformatics/btl559>
• He, Cheng-Qiang; Zhi-Xun Xie & Guan-Zhu Han et al. (2009), "Homologous Recombination as an Evolutionary Force in the Avian Influenza A Virus", Molecular Biology and Evolution 26 (1): 177–187, <http://dx.doi.org/10.1093/molbev/msn238>
• Iwami, S.; T. Suzuki & Y. Takeuchi (2009), "Paradox of Vaccination: Is Vaccination Really Effective against Avian Flu Epidemics?", PLoS ONE 4 (3): e4915, <http://dx.doi.org/10.1371/journal.pone.0004915>
• Klenk, H. -D.; Mikhail N. Matrosovich & J. Stech, eds. (2008), Avian influenza, Karger. Pp. 294, ISBN 3805585012, <http://books.google.com/books?id=BsFo_f90aLoC&printsec=frontcover&source=gbs_summary_r&cad=0#PPP1,M1>
• Lee, Chang-Won & Yehia M. Saif (2009), "Avian influenza virus", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 301–310, <http://dx.doi.org/10.1016/j.cimid.2008.01.007>
• Lupiani, Blanca & Sanjay M. Reddy (2009), "The history of avian influenza", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 311–323, <http://dx.doi.org/10.1016/j.cimid.2008.01.004>
• Minh, Phan Q.; Roger S. Morris & Birgit Schauer et al. (2009), "Spatio-temporal epidemiology of highly pathogenic avian influenza outbreaks in the two deltas of Vietnam during 2003–2007", Preventive Veterinary Medicine 89 (1-2): 16–24, <http://dx.doi.org/10.1016/j.prevetmed.2009.01.004>
• Pappaioanou, Marguerite (2009), "Highly pathogenic H5N1 avian influenza virus: Cause of the next pandemic?", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 287–300, <http://dx.doi.org/10.1016/j.cimid.2008.01.003>
• Sandrock, Christian (2009), "Editorial, Special Issue on Avian Influenza", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 253–254, <http://dx.doi.org/10.1016/j.cimid.2008.01.008>
• Schrijver, Remco S. & Guus Koch, eds. (2005), Avian influenza: prevention and control, Springer. Pp. 152, ISBN 1402034407, <http://books.google.com/books?id=lN8_cxoFfUwC&printsec=frontcover&source=gbs_summary_r&cad=0>
• Spackman, Erica, ed. (2008), Avian influenza virus, Springer. Pp. 141, ISBN 1588299392, <http://books.google.com/books?id=rh8BAKupacUC&printsec=frontcover&source=gbs_summary_r&cad=0>
• Sui, Jianhua; William C Hwang & Sandra Perez et al. (2009), "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", Nature Structural and Molecular Biology 16 (3): 265–273, <http://www.nature.com/doifinder/10.1038/nsmb.1566>
• Swayne, David E. (2009), "Avian influenza vaccines and therapies for poultry", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 351–363, <http://dx.doi.org/10.1016/j.cimid.2008.01.006>
• Ward, M. P.; D. N. Maftei & C. L. Apostu et al. (2009), "Association Between Outbreaks of Highly Pathogenic Avian Influenza Subtype H5N1 and Migratory Waterfowl (Family Anatidae) Populations", Zoonoses and Public Health 56 (1): 1–9, <http://dx.doi.org/10.1111/j.1863-2378.2008.01150.x>
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• Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5 (2005), "Avian Influenza A (H5N1) Infection in Humans", New England Journal of Medicine 353 (13): 1374–85, <http://content.nejm.org/cgi/reprint/353/13/1374.pdf>
• Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus (2008), "Update on Avian Influenza A (H5N1) Virus Infection in Humans", New England Journal of Medicine 358 (3): 261–273, <http://content.nejm.org/cgi/reprint/358/3/261.pdf>
• Yee, Karen S.; Tim E. Carpenter & Carol J. Cardona (2009), "Epidemiology of H5N1 avian influenza", Comparative Immunology, Microbiology and Infectious Diseases 32 (4): 325–340, <http://dx.doi.org/10.1016/j.cimid.2008.01.005>
• Yuan, Puwei; Mark Bartlam & Zhiyong Lou et al. (4 February 2009), "Crystal structure of an avian influenza polymerase PA reveals an endonuclease active site", Nature Online, <http://dx.doi.org/10.1038/nature07720>

External links

Wikinews has related news: Category:Avian Flu

International

United Nations System Coordinator for Avian and Human Influenza (UNSIC).

• Avian Influenza and the Pandemic Threat

World Health Organisation (WHO)

• WHO Avian influenza resource
• The United Nation's World Health Organization's Avian Flu Facts Sheet for 2006

Food and Agriculture Organization of the UN (FAO)

• FAO Avian Influenza portal Information resources, animations, videos, photos
• FAO Bird Flu disease card

World Organisation for Animal Health (OIE)

• Official outbreak reports by country
• Official outbreak reports by week

• Avian influenza resource By Dr. Nati Elkin - Atlases, vaccines and information.

United States

• PandemicFlu.Gov U.S. Government avian and pandemic flu information
• US Avian Influenza Response U.S. Agency for International Development (USAID)
• Avian influenza research and recommendations National Institute for Occupational Safety and Health
• Influenza Research Database Database of influenza sequences and related information.
• Wildlife Disease Information Node A part of the National Biological Information Infrastructure and partner of the NWHC, this agency collects and distributes news and information about wildlife diseases such as avian influenza and coordinates collaborative information sharing efforts.
• Avian Influenza information AVMA - The American Veterinary Medical Association.

Europe

• Health-EU Portal EU response to Avian Influenza.
• Avian Influenza: Prevention and Control Proceedings of the Frontis workshop on Avian Influenza: Prevention and Control, Wageningen, The Netherlands
• Avian Influenza: Questions & Answers European Centre for Disease Prevention and Control - Official website
• FluTrop: Avian Influenza Research in Tropical Countries French Agricultural Research Center for Developing Countries (CIRAD), Avian Influenza website